Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The oral LD50 of potassium hexafluorophosphate in male rats is 1400 ± 78 mg/kg bw.  

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
unknown
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
no guideline followed
Principles of method if other than guideline:
Original publication not available. The study was conducted before 1965.
GLP compliance:
no
Test type:
other: not specified; original publication not available.
Specific details on test material used for the study:
no specific details provided.
Species:
rat
Strain:
not specified
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: 270 days
- Weight at study initiation: 319 - 397 g
Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
original publication not available
Doses:
Not specified. Original publication not available
No. of animals per sex per dose:
Not specified. In total, 29 animals were tested.
Control animals:
not specified
Details on study design:
original publication not available
Preliminary study:
not described
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 1 400 mg/kg bw
Based on:
test mat.
Mortality:
original publication not available
Clinical signs:
other: original publication not available
Gross pathology:
original publication not available
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The acute oral toxicity (LD50) of the test item was determined to be in the range of 1400 ± 78 mg/kg bw in male rats.
Executive summary:

In an acute oral toxicity study published in the handbook “Fluorine Chemistry IV”, male rats were given a single oral dose of potassium hexafluorophosphate and observed for 24 h.

Oral LD50 Males = 1400 ± 78 mg/kg bw     

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
1 400 mg/kg bw

Additional information

According to handbook data, the oral LD50 of potassium hexafluorophosphate in male rats is 1400 ± 78 mg/kg bw.  

Supporting studies, which have been carried out via the intraperitoneal route, resulted in a LD50 of 460 ± 42 mg/kg bw in female rats and a maximal non-lethal dose of 960 mg/kg bw or minimal lethal dose of 1120 mg/kg bw, respectively, in female mice.

These data allow to classify potassium hexafluorophosphate as Category 4 based on GHS criteria regarding acute oral toxicity.

Justification for classification or non-classification

The test item was classified as Category 4 based on GHS criteria.