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Diss Factsheets
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EC number: 203-380-8 | CAS number: 106-27-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Short-term toxicity to fish:
The toxicity of Isoamyl butyrate to fish was predicted from the read-across substance Isoamyl isovalerate (CAS no. 659 -70 -1) (see also the read-across justification).
Both substances have a similar chemical structure and corresponding physicochemical properties. In addition they show similarity in their environmental fate such as biodegradability and their ecotoxic effects on aquatic organisms. Isoamyl isovalerate is therefore proposed suitable to predict the short-term toxicity to fish of the target substance Isoamyl butyrate.
Key study: The toxicity of the read-across substance (Isoamyl isovalerate) to fish was determined in a reliable GLP study according to OECD 203. The LC50 of 3.47 mg/L was estimated based on geometric mean measured concentrations. The recalculated value to correct differences in molecular weight between source (MW = 172.270 g/mol) and target (MW = 158.240 g/mol) was 3.19 mg/L.
Short-term toxicity to aquatic invertebrates:
The toxicity of the test substance to Daphnia magna was determined in a reliable GLP study according to OECD 202. After 48 hours exposure, an EC50 value of 8.12 mg/L (geometric mean measured) was estimated.
Toxicity to aquatic algae and cyanobacteria:
The toxicity of the test substance to the green freshwater algae Pseudokirchneriella subcapitata was determined in a reliable GLP study according to OECD 201. The effect values determined were the growth rate inhibition (ErCx) and the inhibition of yield (EyCx) after 72 hours. The respective values were ErC50 = 4.68 mg/L, ErC10 = 3.13 mg/L, EyC50 = 3.84 mg/L and EyC10 = 1.23 mg/L (based on geometric mean measured concentrations).
Toxicity to microorganisms:
The biodegradation of Isoamyl butyrate was determined in a reliable biodegradation test (OECD 310) including a toxicity control. No inhibitory effects were observed on microorganisms at a substance concentrations of 15.1 mg/L. The activated sludge test was, therefore, waived.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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