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EC number: 209-527-2 | CAS number: 584-03-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 June 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Non-GLP, non-guidline with deviation from the curent guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Guideline:
- other: Method according to Smyth et al. Am. Ind. Hyg. Ass. J. 23, 95-107, 1962
- GLP compliance:
- no
- Test type:
- other: standard acute inhalation method
- Limit test:
- no
Test material
- Reference substance name:
- Butane-1,2-diol
- EC Number:
- 209-527-2
- EC Name:
- Butane-1,2-diol
- Cas Number:
- 584-03-2
- Molecular formula:
- C4H10O2
- IUPAC Name:
- butane-1,2-diol
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Firma Wiga, Sulzfeld
- Age at study initiation: Not reported
- Weight at study initiation: ca. 212 g
- Fasting period before study: Not specified.
- Housing: Not reported
- Diet (e.g. ad libitum): Altromin-R (Altrogge, Lage/Lippe), ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: Not reported
ENVIRONMENTAL CONDITIONS : Not reported
- Temperature (°C):
- Humidity (%):
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light):
IN-LIFE DATES: Not reported
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- The product was placed in an approximately 5 cm high fritted glass bottle which was located in a water bath at 20°C. Through the product flows an air volume of 200 liters / hour. The vapor of the substance-enriched air stream was distributed to glass inhalation chambers. The exposure times were 3, 10 and 30 minutes and 1, 3 and 7 hours.
- Analytical verification of test atmosphere concentrations:
- not specified
- Remarks on duration:
- 7 hours
- Concentrations:
- 370 mg/L air
- No. of animals per sex per dose:
- 12
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days - Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, pathology - Statistics:
- Not specified
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 370 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Remarks:
- Effect levels were calculated using a vapour pressure of 10 Pa and rate of exposure of the substance in air per animal of 200 L of ‘air’/hour over 7 hours.
- Mortality:
- No mortality throughoout the study period
- Clinical signs:
- other: Slight mucosal irritation and rapid breathing.
- Body weight:
- Not reported
- Gross pathology:
- No relevant pathological findings in the organs.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of the study, the inhalation 7h-LC50 (male/female) was considered to be > 370 mg/L air.
- Executive summary:
The study was performed according to Method according to Smyth et al. Am. Ind. Hyg. Ass. J. 23, 95-107, 1962 to assess the acute inhalation toxicity of the substance. The substance was filled in approx. 5 cm high a frit bottle made of glass, which was placed in a water bath at 20°C. The product flows through an air volume of 200 litres / hour. The vapor of the substance-enriched air stream was distributed to glass inhalation chambers. A single group of 12 Sprague-Dawley strain rats (males and females) were exposed to an air stream at 3, 10 and 30 minutes or 1, 3 and 7 hours and a follow-up period is 14 days.
The following investigations were conducted:
a) mortality
b) Poisoning symptoms
c) Section of those that have died and those after the follow-up time were killed with carbon dioxide
No mortality observed after 7 hours exposure and throughout the observation period. Slight mucosal irritation and rapid breathing were noted. No relevant pathological findings in the organs were observed.
Therefore, the LC50 was determined
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