Registration Dossier
Registration Dossier
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EC number: 222-872-3 | CAS number: 3644-12-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 492 (Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- N-(methoxymethyl)methacrylamide
- EC Number:
- 222-872-3
- EC Name:
- N-(methoxymethyl)methacrylamide
- Cas Number:
- 3644-12-0
- Molecular formula:
- C6H11NO2
- IUPAC Name:
- N-(methoxymethyl)-2-methylacrylamide
- Test material form:
- liquid
Constituent 1
Results and discussion
In vitro
Results
- Irritation parameter:
- other: reduction in optical density
- Run / experiment:
- 1
- Value:
- 25.9
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- positive indication of irritation
- Remarks:
- The relative absorbance values were reduced to 25.9%. This value is well below the treshold value for eye irritation potential (60%)
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
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