Registration Dossier
Registration Dossier
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EC number: 242-286-1 | CAS number: 18407-07-3
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: screening test, other
- Remarks:
- enhanced ready biodegradability test (60 d)
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the attached justification below and the overall justification for grouping of substances attached in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Parameter:
- % degradation (O2 consumption)
- Value:
- 41
- Sampling time:
- 28 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 39
- Sampling time:
- 60 d
- Conclusions:
- Dichlorododecylmethylsilane (CAS 18407-07-3) is regarded as not readily biodegradable (41%, 28 days) and not inherently biodegradable (39% biodegradation, 60 days) based on an extended OECD 301F test on the read across substance chloro(dodecyl)dimethylsilane (CAS 66604 -31 -7).
Reference
Description of key information
Dichlorododecylmethylsilane (CAS 18407-07-3) is regarded as not readily biodegradable (41%, 28 days) and not inherently biodegradable (39% biodegradation, 60 days) based on an extended OECD 301F test on the read across substance chloro(dodecyl)dimethylsilane (CAS 66604 -31 -7).
Key value for chemical safety assessment
Additional information
There are no data on biodegradation for dichlorododecylmethylsilane (CAS 18407-07-3). In accordance with Regulation (EC) No. 1907/2006 Annex XI, 1.5 “Grouping of substances and read across” and in accordance with the read across assessment framework (RAAF, ECHA 2017) a read across from the analogue substance chloro(dodecyl)dimethylsilane (CAS 66604-31-7) has been applied to support the environmental hazard assessment of the substance. Details on the read across justification can be found in the attached justification in the respective target entry and in the overall justification for grouping of substances attached in IUCLID Section 13.
The available study (2017) investigating the biodegradation of the analogue substance chloro(dodecyl)dimethylsilane (CAS 66604-31-7) was conducted according to OECD guidance 301F and GLP standards. The inoculum (non-adapted activated sludge from a sewage treatment plant) was exposed for 60 days to 20 mg/L test substance and biodegradation was calculated based on O2 consumption. The substance reached a biodegradation value of 41% after 28 d and 39% after 60 d. Therefore, the read across substance is considered as not readily and not inherently biodegradable within 28 d / 60 days.
Based on the results of the analogue substance, dichlorododecylmethylsilane (CAS 18407-07-3) is assumed not readily biodegradable and not inherently biodegradable.
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