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EC number: 218-528-7 | CAS number: 2173-56-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18.Aug. 2016 to 13. Sept. 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- yes
- Remarks:
- not critical (no air condition for several hours in the room with the cages)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- certified by Slovak National Acreditation Service, Karloeská 63, 840 00 Bratislava 4, Slovak Republic
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Pentyl valerate
- EC Number:
- 218-528-7
- EC Name:
- Pentyl valerate
- Cas Number:
- 2173-56-0
- Molecular formula:
- C10H20O2
- IUPAC Name:
- pentyl valerate
- Test material form:
- liquid
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA/Ca
- Sex:
- male
- Details on test animals and environmental conditions:
- Source: AnLab Prague (Czech Republic), 29 females (non-pregnant, nulliparous), 6 days acclimated, 10 weeks old at first dose, healthy,
housing, diet, water, bedding according guideline, animal identification by marking with a permanent penn on the tail,
The study was approved by State Veterinary and Food Administration of SR according to national requrements for the protection of animals
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- pre-screen test: undiluted (100%)
main study: 100%, 50%, 25% - No. of animals per dose:
- 2 for pre-screen-test, application on both ears
5 for main study, application on both ears
5 negative control (vehicle), application on both ears
5 positive control, applicationon both ears - Details on study design:
- Pre-screen test: undiluted test substance (100%) was applicated to both ears, no effects (clinical signs, local irritation) seen
Main study: conentrations of 100, 50 and 25% were applicated to both ears. Clinical signs and erythema at the ears were checked dayly, ear thickness every second day, body weight before and at the end of the study. At day 6 (last day of the study) radioactive I-iododeoxyuridine (2µCi in 250µl) was injected in the tail vein. Five hours later the animals were killed and the auricular lymph nodes were taken. All lymph nodes of one dose group were given together, weighed and prepared in a cell suspension. The cellular proliferation was determined by as incorporated radioactivity by an automatic gamma counter as counts per minute. A disintegration per minute (DPM) per dose group and a stimulation index (SI) were calculated. - Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
- Statistics:
- pooled treatment group approach, no statistics for SI
Results and discussion
- Positive control results:
- SI = 5,42
In vivo (LLNA)
Resultsopen allclose all
- Key result
- Parameter:
- SI
- Value:
- 1.58
- Key result
- Parameter:
- SI
- Value:
- 1.83
- Key result
- Parameter:
- SI
- Value:
- 1.89
- Cellular proliferation data / Observations:
- pre-screening test: no clinical signs
main study: no clinical signs observed, dose-dependant increase in pooled lymph node weights and DPM values, SI (except positive control group) under the threshold of 3, therefore not sensitizng in this test
Any other information on results incl. tables
Main study: 5 test groups: Negative control (vehicle), positive control, test substance: 25%, 50%, 100%, dose-dependent lymph node weights and DPM values
all SI < 3 => therefore not sensitizing in this test
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Pentyl valerate is not a skin sensitizer in the LLNA
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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