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EC number: 218-507-2 | CAS number: 2167-23-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Date: 14 June 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- fixed dose procedure
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- Di-tert-butyl sec-butylidene diperoxide
- EC Number:
- 218-507-2
- EC Name:
- Di-tert-butyl sec-butylidene diperoxide
- Cas Number:
- 2167-23-9
- Molecular formula:
- C12H26O4
- IUPAC Name:
- 2,2-bis(tert-butylperoxy)butane
- Reference substance name:
- White mineral oil (petroleum)
- EC Number:
- 232-455-8
- EC Name:
- White mineral oil (petroleum)
- Cas Number:
- 8042-47-5
- Molecular formula:
- C15H32 - C50H102
- IUPAC Name:
- White mineral oil (petroleum)
- Test material form:
- liquid
Constituent 1
additive 1
- Specific details on test material used for the study:
- A 1kg sample of the test material was received from the principal on April 9, 1979. It was a clear colourless liquid, designated Trigonox D-E50, and coded nr. 5478090039. The material was stated to be a 50% solution of 2,2 di-tert-butyl-peroxybutane in mineral oil.
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Young adult albino rats (Wistar derived) from the Institute's colony were used. The body weights of males varied from 185 to 263 g, those of females from 103 to 142 g. The rats were housed in groups of five screen-bottomed stainless steel cages, in a well-ventilated room, maintained at 23±1°C. Before dosing the rats were fasted overnight.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Remarks:
- mineral oil
- Details on oral exposure:
- After some preliminary observations, the test material was given undiluted by gavage to groups of ten males and ten females in one single dose of 30.0 ml per kg body weight. This dose is considered to be the highest tolerable amount to be given in a single dose.
- Doses:
- 30.0 ml per kg body weight
- No. of animals per sex per dose:
- 10 males and 10 females per dose.
- Control animals:
- no
- Details on study design:
- After treatment, the rats received stock diet and water ad libitum. The were observed for signs of intoxication during a 14-day period, after which autopsies were carried out on the survivors.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 30 mL/kg bw
- Based on:
- test mat.
- Mortality:
- There were no deaths.
- Clinical signs:
- Within a few hours after treatment the rats showed sluggishness humpback behaviour and severe diarrhoea. Later on the rats recovered gradually and looked quite healthy again at the end of the observation period.
- Gross pathology:
- Macroscopic examination of the survivors at autopsy did not reveal any treatment-related gross alterations.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- From the results, it appears that the LD50 of Trigonox D-E50 exceeds 30 ml per kg bodyweight. Therefore, the material can be classified as relatively harmless.
- Executive summary:
From the results, it appears that the LD50 of Trigonox D-E50 exceeds 30 ml per kg bodyweight (24.34 g/kg bw, based on density, 0.8114).
Therefore, the material can be classified as relatively harmless.
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