4,4'-bis(chloromethyl)-1,1'-biphenyl

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

19 April 2016 to 21 April 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 187

Deviations:

no

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

Laser scattering/diffraction

Type of particle tested:

agglomerate

Type of distribution:

volumetric distribution

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source: Provided by sposor
- Lot/batch No.of test material: 150701
- Expiration date of the lot/batch: 14 July 2017

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: - Storage conditions: Controlled room temperature (15-25 ºC, below 70 RH%), protected from humidity, under inert gas.

Mass median aerodynamic diameter:

>= 554.13 - <= 565.76 µm

Geometric standard deviation:

>= 1.774 - <= 1.829

Key result

Percentile:

D10

Mean:

207.626 µm

St. dev.:

8.052

Remarks on result:

other: Standard deviation of the population reported.

Key result

Percentile:

D50

Mean:

508.937 µm

St. dev.:

3.952

Remarks on result:

other: Standard deviation of the population reported.

Key result

Percentile:

D90

Mean:

883.739 µm

St. dev.:

4.953

Remarks on result:

other: Standard deviation of the population reported.

No.:

#1

Size:

< 10 µm

Distribution:

0.31 %

Table 1. Full particle size test results

	RUN 1	RUN 2	RUN 3	RUN 4	RUN 5	**Average
Volume weighted Mean	530.577	520.860	531.571	531.170	531.494	529.134
Median (d.50)	510.431	501.070	510.875	510.729	511.582	508.937
Mode (μm)	558.958	551.977	558.803	556.656	558.373	556.945
*MMAD	564.48	554.13	564.97	564.81	565.76	562.83
10 % of material is <	206.779	192.853	208.828	214.744	214.762	207.626
50 % of material is <	510.431	501.070	510.875	510.729	511.582	508.937
90 % of material is <	887.636	874.262	887.872	883.959	884.510	883.739

All results are in μm

* Mass Median Aerodynamic Diameter

** Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.

0.31 % by volume of sample was seen to be < 10.00 μm.

Standard Deviation Results

Run No.	1	2	3	4	5	STDVP	% STDVP
D10	206.779	192.853	208.828	214.744	214.762	8.025	3.9
D50	510.431	501.070	510.875	510.729	511.582	3.952	0.8
D90	887.636	874.262	887.872	883.959	884.510	4.953	0.6
D15.78	283.475	273.962	284.755	287.852	287.869	5.110	1.8
GSD	1.801	1.829	1.794	1.774	1.777	0.020	1.1
MMAD	564.48	554.13	564.97	564.81	565.76	4.37	0.8

GSD = Geometric standard deviation of the lognormal particle size distribution

STDVP = standard deviation of the population

% STDVP = percentage standard deviation of the population

Coefficient of variation for d50 is less than 3 %; d10 and d90 are less than 5 %. Thus repeatability of the characteristic particles in the size distribution are within the acceptable limits as per the ISO 13320-1 test standard.

Conclusions:

Under the conditions of this study the average size of the particles was determined to be 508.937 microns.

Executive summary:

A determination of the particle size distribution of the test material was carried out in accordance to the standardised guidelines ISO 13320:2009, CIPAC MT 187 with consideration of OECD 110 under GLP conditions.

The particle size of the test material was determined through laser diffraction using a particle size analyser. The sample proved to be insoluble, and well dispersed in methanol, therefore methanol was used for the suspension fluid. 5 runs were perfomed to ensure repeatability of results.

Under the conditions of this study the average size of the particles was determined to be 508.937 microns.

Description of key information

Under the conditions of this study the average size of the particles was determined to be 508.937 microns.

Additional information

A determination of the particle size distribution of the test material was carried out in accordance to the standardised guidelines ISO 13320:2009, CIPAC MT 187 with consideration of OECD 110 under GLP conditions. The study was assigned a reliability score of 1 in accordance with the criteria for assessing data quality set forth by Klimisch et al. (1997).

The particle size of the test material was determined through laser diffraction using a particle size analyser. The sample proved to be insoluble, and well dispersed in methanol, therefore methanol was used for the suspension fluid. 5 runs were perfomed to ensure repeatability of results.

Under the conditions of this study the average size of the particles was determined to be 508.937 microns.