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Diss Factsheets
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EC number: 947-036-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March - April, 2019
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- July 17, 1992
- Deviations:
- yes
- Remarks:
- Preliminary test only
- Principles of method if other than guideline:
- A preliminary concentration range-finding test was conducted to determine the approximate toxicity of the test item so that appropriate test concentrations could be selected for use in the definitive test. Four fish were exposed to each concentration of the test item plus a control, for 96 hours under semi-static conditions.
It was not possible to perform the main study when it became clear that the substance was used only in personal care products. - GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Formulation: A stock solution with a concentration of 100.0 mg/L (nominal) was prepared with direct addition of the test item, mixed into the test medium (aquarium water). The test solutions were prepared by appropriate diluting of this stock solution just before introduction of the fish - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebra fish
- Source: Szent István University, Department of Aquaculture, 2100 Gödöllő, Páter Károly u. 1., Hungary
ACCLIMATION
- Acclimation period: > 12 days
- Health during acclimation (any mortality observed): Fish were observed during the acclimatisation and test periods; the fish were healthy. There was no mortality of the population for seven days before the test.
FEEDING DURING TEST
The fish were not fed during the test. - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Nominal and measured concentrations:
- 0.1, 1, 10 or 100 mg/L (nominal)
- Details on test conditions:
- Four fish used per dose level.
The frequency of the water renewal periods was 24 hours. - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 0.1 - < 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- Localisation at the bottom of the aquarium or close to the surface of the water, swimming problems (decreased activity) and fast motility of operculum were observed at 1.0 mg/L (nominal) during the first 6 hours.
- Sublethal observations / clinical signs:
Results of the preliminary range-finding test
Nominal Concentration [mg/L]
control
0.1
1
10
100
Number of treated animals
4
4
4
4
4
Number of dead animals
0 0 4 4 4 - Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on the preliminary range-finding study, the 96-h LC50 for Danio rerio is between 0.1 and 1 mg/L.
- Executive summary:
A study was performed according to OECD TG 203 using Zebra fish (Danio rerio). A preliminary concentration range-finding test was conducted to determine the approximate toxicity of the test item so that appropriate test concentrations could be selected for use in the definitive test. Four fish were exposed to each concentration of the test item plus a control, for 96 hours under semi-static conditions. The frequency of the water renewal periods was 24 hours. No fish died at 0.1 mg/L, whereas all fish at 1 mg/L and higher doses died. Based on these results, the LC50 is estimated to be in the range of 0.1 to 1 mg/L.
It was not possible to perform the main study when it became clear that the substance was used only in personal care products.
Reference
Description of key information
96 -h LC50 (Danio rerio) is estimated to be in the range of 0.1 to 1 mg/L
Key value for chemical safety assessment
Additional information
A study was performed according to OECD TG 203 using Zebra fish (Danio rerio). A preliminary concentration range-finding test was conducted to determine the approximate toxicity of the test item so that appropriate test concentrations could be selected for use in the definitive test. Four fish were exposed to each concentration of the test item plus a control, for 96 hours under semi-static conditions. The frequency of the water renewal periods was 24 hours. No fish died at 0.1 mg/L, whereas all fish at 1 mg/L and higher doses died. Based on these results, the 96 -h LC50 is estimated to be in the range of 0.1 to 1 mg/L.
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