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Diss Factsheets
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EC number: 219-376-4 | CAS number: 2426-08-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- To evaluate the acute percutaneous toxicity of the test substance, 2 male and 2 female rabbits per dose level were treated with 1000, 750, or 500 mg/kg bw.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Butyl 2,3-epoxypropyl ether
- EC Number:
- 219-376-4
- EC Name:
- Butyl 2,3-epoxypropyl ether
- Cas Number:
- 2426-08-6
- Molecular formula:
- C7H14O2
- IUPAC Name:
- 2-(butoxymethyl)oxirane
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ray Nichols Rabbitry, Lumberton, Texas.
- Housing: Housed singly
- Diet: Commercial laboratory chow (Palston Purina Company, St Louis, Missouri), ad libitum.
- Water: Well water, ad libitum.
- Acclimation period: At least 1 week
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: The entire trunk was clipped free of hair with electric clippers.
- Type of wrap if used: The undiluted test material was applied under a heavy-gauge plastic sleeve held in place with rubber bands. The plastic sleeve was covered with a cloth bandage taped securely to the marginal hair.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The sleeves were removed and the skins were washed with mild soap and water, rinsed thoroughly, and dried with a soft disposable towel.
- Time after start of exposure: After 24 hours - Duration of exposure:
- 24 hours
- Doses:
- 1000, 750, and 500 mg/kg bw
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The topical response at the test site of application was evaluated after removal of the plastic sleeve. The animals were observed frequently during exposure and for the following 2 weeks for signs of toxicity.
- Necropsy of survivors performed: At 2 weeks post-treatment, all surviving rabbits were submitted for gross pathological examination. - Statistics:
- The acute percutaneous absorption LD50 was calculated by the moving average method as implemented in a computer program.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 778 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 642 - <= 1 012
- Mortality:
- At 1000 mg/kg bw: 4/4 rabbits died.
At 750 mg/kg bw: 1/4 rabbits died.
At 500 mg/kg bw: 0/4 rabbits died. - Clinical signs:
- other: Following treatment, the rabbits displayed signs of discomfort and became lethargic. The treated skin was necrotic with scabbing and scarring.
- Gross pathology:
- No internal lesions attributable to treatment were observed in the survivors upon gross pathological examination at 2 weeks.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
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