Registration Dossier
Registration Dossier
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EC number: 413-060-1 | CAS number: 19186-97-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study done at Universiteit Utrecht using method developed specially for testing highly hydrophobic chemicals (slow stirring method).
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)
- Principles of method if other than guideline:
- Water and octanol were mutually saturated with each other. FR-370 was dissolved in water saturated octanol and subsequently equilibrated with water (saturated with water). Equilibration of the two phases occured in the slow-stirring experiment, in which the two immiscible phases are are gently stirred such that the formation of octanol-microdroplets is prevented. Three independent reactors are used in this experiment.
After equilibration has occured, replicate water and octanol samples are withdrawn from each reactor and subjected to chemical analysis for the concentration of FR-370 in both phases. For each reactor an average value of Log POW and its variance are determined. These data are employed to calculate a variance-weighted average of the three reactors. This value represent the slow stirring Log POW value of FR-370 determined in the present study. - GLP compliance:
- no
- Remarks:
- non GLP study
- Type of method:
- other: slow stirring method
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- 4.87
- Temp.:
- 298 K
- pH:
- > 6 - < 7
- Details on results:
- See attached document on results
- Conclusions:
- Log POW of FR-370 using slow stirring method (using three replicates): 4.871±0.003
Reference
Description of key information
4.871±0.003
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4.87
- at the temperature of:
- 20 °C
Additional information
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