Registration Dossier
Registration Dossier
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EC number: 201-969-4 | CAS number: 90-15-3
Carcinogenicity
Administrative data
Description of key information
A non-oxidative hair dye formulation containing 0.5% 1-naphthol together with 12 other dye ingredients has been tested for carcinogenicity in mice and rats by topical application. No increase in tumour frequency was found. No conclusion with regard to carcinogenicity can, however, be made from the studies due to the low concentration of 1-naphthol used and the fact that the experimental procedure used did not give any response when 2,4 -diaminoanisole (EU, carcinogenic Category 2) was tested.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
A non-oxidative hair dye formulation containing 0.5% 1 -naphthol has been tested for carcinogenicity in mice and rats by topical application. No increase in tumour frequency was found. No conclusion with regard to carcinogenicity can, however, be made from the studies due to the low concentration of 1 -naphthol used.
Additional information
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