Registration Dossier
Registration Dossier
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EC number: 605-146-4 | CAS number: 158451-78-6
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
The test substance was found to be not readily biodegradable in an OECD 301B and not inherently biodegradable in an OECD 302B guideline study.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
The biodegradation potential of the substance in water was determined in two screening studies.
In the first study, the ready biodegradability of the substance was examined according to OECD TG 301B (CO2 Evolution Test) and in compliance with GLP criteria. In this study, ca. 161 mg/L the test substance (corresponding to 20 mg/LTOC) was inoculated with activated sludge from a predominantly domestic sewage for 28 days under aerobic conditions. At regular intervals throughout the incubation period the evolved CO2, measured as mg total inorganic carbon (TIC), was determined and compared to the ThCO2 as indication of biodegradation. Additionally, dissolved organic carbon (DOC) concentration was determined at the start and after 28 days exposure. Based on CO2/ThCO2, 20 - 30% of the test substance was biodegraded after the 28 -day exposure period. Based on DOC measurements, biodegradation was 20%.
In a second study, the inherent
biodegradability was examined according to OECD TG 302B
(Zahn-Wellens/EMPA Test) and in compliance with GLP criteria. In this
study, ca 2044 mg/L test substance was inoculated with activated sludge
from a predominantly domestic sewage for 28 days under aerobic
conditions. At regular intervals throughout the incubation period the
concentration of dissolved organic carbon was measured as indication of
biodegradation. After the 28 -day exposure period, 10 - 20% of the test
substance was biodegraded. Overall, the substance was determined to be
poorly eliminable from water.
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