Registration Dossier
Registration Dossier
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EC number: 212-686-0 | CAS number: 846-48-0
Endpoint summary
Administrative data
Description of key information
Oral (Rat, GLP): LD50 > 2000 mg/kg
[Bayer Schering Pharma AG, Report No. A49531, 2010-06-14]
Dermal (Rat, GLP): LD50 > 2000 mg/kg
[Bayer Schering Pharma AG, Report No. A49585, 2010-06-17]
Key value for chemical safety assessment
Additional information
The single oral administration of the boldenone (ZK 5320) to male and female rats at a dose of 2000 mg/kg resulted in increased salivation, decreased motility, digging, cleaning movements and piloerection in 2 out of 3 female animals. One rat was sacrificed in moribund status provoked by incidental misapplication. The acute oral toxicity of boldenome in rats is above 2000 mg/kg body weight. (Bayer Schering Pharma AG, Report No. A49531, 2010-06-14 )
The single dermal administration of boldenone to male and female rats in the doses of 2000 mg/kg was tolerated without any compound-related clinical or macroscopic pathological signs. LD50 > 2000 mg/kg (Bayer Schering Pharma AG, Report No. A49585, 2010-06-17)
Justification for classification or non-classification
Due to the results (LD50 > 2000 mg/kg) in the dermal and oral acute toxicity tests classification according to Directive 67/548/EEC and Regulation 1272/2008/EC is not required.
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