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EC number: 230-819-0 | CAS number: 7328-91-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to fish:
In a non-GLP study according to DIN 38 412, part L15, the acute fish toxicity of 2,2-dimethylpropane-1,3-diamine (DMPDA, CAS 7328-91-8) to Leuciscus idus was studied. Based on nominal concentrations, the 96 -h LC50 was determined to be 146.6 mg/L. (BASF AG, 1988; Report No. 10F/0641/875057).
Based on the available experimental data it can be concluded, that DMPDA is with high probability acutely not harmful to fish.
Short-term toxicity to aquatic invertebrates:
No experimental data on the short-term toxicity of DMPDA (CAS 7328-91-8) to aquatic invertebrates are available. In order to assess the short-term toxicity potential of DMPDA, EC50 values were calculated with the estimation model (Q)SAR Toolbox v4.1 using three valid profiling variations (for details see IUCLID chapter 6.1.3).
Considering all profiling variations applied, the model (Q)SAR Toolbox v4.1 calculated for DMPDA (CAS 7328-91-8) 48-h EC50 values ranging from 134 to 307 mg/L; in all cases the substance was within the applicability domain of the estimation model. As a worst-case approach, the lowest value available (48-h EC50 = 134 mg/L) was selected as key value for the chemical safety assessment.
Based on a weight-of-evidence approach by the available estimated data, the substance is concluded to be with high probability not harmful to aquatic invertebrates.
Toxicity to aquatic algae and cyanobacteria:
No experimental freshwater data are available. The substance was tested under marine conditions according to ISO 10253 (Eide-Haugmo, 2012), using Skeletonema costatum as test organism. The 72-h ErC50 was determined to be 483 mg/L.
Based on the available experimental marine data the substance is considered to be with high probability not harmful to aquatic algae and cyanobacteria. This study was selected as key study for the chemical safety assessment.
Toxicity to microorganisms:
The key study with Pseudomonas Putida was conducted according to DIN 38412 -8. The EC50 was determined to be184.8 mg/L after 17 h. (BASF AG, 1987)
A supporting non-GLP study was performed according to ISO 8192. Industrial activated sludge was exposed to DMPDA (CAS 7328-91-8). The EC50 was above 800 mg/L after 180 min (BASF AG, 1987).
Based on the available experimental data it can be concluded, that the inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.
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