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Diss Factsheets
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EC number: 815-961-9 | CAS number: 1374760-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental dates: 2017-10-13 to 2017-10-17
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study was conducted according to an internationally recognised method, and under GLP. No significant deviation was reported. The test substance is adequately characterised. Therefore full validation applies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- (1995)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- Regulation (EC) No.440/2008 (as updated by Regulation (EC) No.260/2014)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Inspection June 7th-10th,2016 and July 13th,2016. Signed Jan. 03rd, 2017.
- Type of method:
- flask method
- Key result
- Water solubility:
- 13.2 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- ca. 24 - ca. 72 h
- Temp.:
- 20 °C
- pH:
- ca. 6.5
- Details on results:
- The analytical method was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity:
Linearity
Range: 0.25 – 10 mg/L with r2 = 0.9997 (n=6)
Limit of Quantification = 1 mg/L.
Accuracy
Recovery rates were 98% for the 1 x LOQ (RSD=0.61%, n=5) and 102% for the 10 x LOQ (RSD=0.13%, n=5).
Specificity
Comparison of spectra of sample peaks against spectra obtained from standard peaks verified. Blank values < 30% of the LOQ. - Executive summary:
The water solubility of the test item was determined according to OECD 105 / EC A6 guidelines, under GLP, using the flask method, in double distilled water, at 20°C.
Analytical evaluation was performed using HPLC-DAD. The analytical method was validated with satisfactory results regarding linearity, limit of quantification, accuracy, precision and specificity.
Measurements were performed on duplicate samples for each pre-incubation times (24, 48 and 72 h) at 30°C, with duplicate analysis. Equilibrium was considered achieved at first sampling interval, and the mean result was retained.
The water solubility was determined to be 13.2 mg/L (20 °C, pH 6.5)
Reference
Water solubility results
No Tyndall‑effects were observed for any sample during this study.
Pre-incubation time |
Replicate No. |
Measured |
Water solubility |
|
Concentration |
Mean |
|||
24 h |
1 |
6.614 |
13.2 |
12.7 |
2 |
6.327 |
12.3 |
||
48 h |
1 |
6.443 |
13.7 |
13.6 |
2 |
6.474 |
13.4 |
||
72 h |
1 |
6.769 |
14.0 |
13.4 |
2 |
6.394 |
12.7 |
||
Mean (24 - 72 h) |
|
6.5 +/- 0.2 |
|
13.2 |
Maximum deviation [%] |
|
6.5 |
pH of control: 6.799
Description of key information
Slightly soluble, with equilibrium reached at 24h. pH of saturated solution: ca 6.5.
Key value for chemical safety assessment
- Water solubility:
- 13.2 mg/L
- at the temperature of:
- 20 °C
Additional information
A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as a key study, and the result is retained as key value.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.