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EC number: 247-063-2 | CAS number: 25513-64-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988-06-15 to 1988-06-17
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with national standard methods with acceptable restrictions: Exposure period only 24 hours, incomplete documentation
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 38412 part 11
- Deviations:
- not specified
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- STOCK AND TEST SOLUTION AND THEIR PREPARATION
- Concentration: 10 g/l, no solvent or vehicle - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISMS
- Strain: Daphnia magna, Hüls
- Source/supplier: Hüls AG (inhouse)
- Breeding method: in 1 l jars with dechlorinated drinking water, water renewal each 2-3 days, isolation of juveniles for further breeding ca every
4 weeks
- Age: < 24 hours
- Feeding: Chlorella vulgaris, daily as much as consumed
- Pretreatment: Removal of adults 24 h prior to testing
- Feeding during test: no - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Test temperature:
- 20 +/- 1 degree C
- Nominal and measured concentrations:
- 12; 18; 25; 35; 50; 70; 100 mg/l (nominal)
- Details on test conditions:
- TEST SYSTEM
- Exposure vessel type: 25 ml graduated cylinder
- Number of replicates, individuals per replicate: 4 replicates with 5 individuals each
- Control group: 2 reference substance controls, one blank
- Photoperiod: dark
DILUTION WATER
- Source: Synthetic: CaCl2 x 2 H2O: 294 mg/l; MgSO4 x 7 H2O: 123 mg/l; NaHCO3: 63 mg/l; KCl: 5.5 mg/l
- Ca/Mg ratio: 4:1
- Na/K ratio: 10:1
- Aeration: no
TEST PARAMETER: immobilization - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate, CAS RN 7778-50-9
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- 25 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 31.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 28.9-34.2
- Duration:
- 24 h
- Dose descriptor:
- EC100
- Effect conc.:
- 70 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - EC50 values were calculated according to Cavalli-Sforza (1972)
- the mortality data are presented below (remarks on results) - Results with reference substance (positive control):
- - Concentrations: 0.9 mg/l / 1.9 mg/l
- Results: 30 % immobile / 85 % immobile (24 hours) - Validity criteria fulfilled:
- not specified
- Conclusions:
- The EC50 (24 hours) was determined as 31.5 mg/L indicating that the test substance may be harmful to aquatic invertebrates.
- Executive summary:
The acute toxicity of the test item on Daphnia magna was investigated by Hüls AG (1996) in a 24 -h test according to national guidance documents (DIN 38412, part II). The following endpoint was derived:
EC50 (24 hours): 31.5 mg/L; CL: 28.9 mg/L - 34.2 mg/L.
The study was assessed as "reliable with restrictions".
Reference
RESULTS:
- Effect data (Immobilisation): No. of immobile daphnia
Control: 0 (24 h)
12 mg/l: 0 (24 h)
18 mg/l: 0 (24 h)
25 mg/l: 2 (24 h)
35 mg/l: 16 (24 h)
50 mg/l: 19 (24 h)
70 mg/l: 20 (24 h)
100 mg/l: 20 (24 h)
EC50, 95 % confidence interval: 28.9 - 34.2 mg/l (24 hours)
Description of key information
The acute toxicity of the test item on Daphnia magna was investigated by Hüls AG (1996) in a 24 -h test according to national guidance documents (DIN 38412, part II). The EC50 (24 hours) was determined as 31.5 mg/L (CL: 38.9 - 34.2 mg/L) indicating that the test substance may be harmful to
aquatic invertebrates.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 31.5 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.