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EC number: 814-994-6 | CAS number: 123403-95-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance is acutely not harmful to aquatic organisms
Additional information
No further testing regarding toxicity to another aquatic organism is conducted due to the fact that this endpoint is not mandatory under REACH. However, an acute test on daphniids and the QSAR estimation model ECOSAR were applied in order to examine the aquatic toxicity of 3-(1-ethoxyethyl)-5-methyloxazolidin-2-one (EE-MOX) (CAS 123403-95-2). Moreover, a read-across approach to structurally similar substance was applied to assess the aquatic toxicity of EE_MOX (CAS 123403-95-2). The following source substance was used: 5-Methyl-3- vinyloxazolidin-2-on (CAS 3395-98-0). Chronic toxicity data are available for one trophic level (Algae).
Acute toxicity to fish:
The substance is considered to be with high probability acutely not harmful to fish.
Key study: The EC50 was estimated to be >100 mg/L (neutral organic; BASF SE 2016).
Supporting study: Read-Across to the close structural analogue 5-Methyl-3-vinyloxazolidin-2-on; OECD 201: static GLP study, zebrafish (Danio rerio), nominal concentrations of 0 (control) and 120 mg/L. The 96-h LC50 was >120 mg/L based on the nominal concentration of the test substance.
Acute toxicity to aquatic invertebrates
The substance is acutely not harmful to aquatic invertebrates.
Key study: OECD 202: Daphnia magna, GLP, semi-static, analytical verification of test concentrations, pH adjusted: 48-h EC50 > 120 mg/L (nom.)
Supp. study: In order to support the key study, the EC50 was determined to be >100 mg/L by using estimation model ECOSAR v1.11. (neutral organic; BASF SE 2016). The ECOSAR classifies the substance as a carbamate ester. Due to the poor database available for this chemical class, the substance was estimated with ECOSAR as a neutral organic.
Toxicity to aquatic algae and cyanobacteria
EE-MOX (CAS 123403-95-2) is acutely not harmful to aquatic algae and cyanobacteria.
Key study: The EC50 was estimated to be >100 mg/L and the chronic values (EC10/NOEC) has been identified > 10mg/L by using ECOSAR v1.11. (neutral organic; BASF SE 2016).
Supporting study: Read-Across to the close structural analogue 5-Methyl-3-vinyloxazolidin-2-on; OECD 201, static GLP study, Pseudokirchneriella subcapitata, nominal concentrations of 0 (control) and 120 mg/L. The following effect concentrations were obtained after 72 hours of exposure: ErC50>120 mg/L, NOErC >=120mg/L.
Toxicity to aquatic microorganisms
The inhibition of the degradation activity of activated sludge is not anticipated when the substance is introduced in appropriately low concentrations.
Key study: OECD 209, activated sludge from a domestic sewage treatment plant, the (3 h) EC10 test value was determined to be 160 mg/L. (BASF SE, 2017, rep. no.: 08G0010/17G064).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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