Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 229-904-5 | CAS number: 6829-22-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: short report, in compliance with the guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Five male and five female Wistar rats were given 5000 mg MACROLEX Red CA 51038 (CAS no 6829-22-7)/kg bw dissolved in lutrol and observed for mortality and clinical signs and body weight development over a period of 14 days. Gross pathological examinations were done on all animals sacrificed at the end of study.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 14H-benz[4,5]isoquino[2,1-a]perimidin-14-one
- EC Number:
- 229-904-5
- EC Name:
- 14H-benz[4,5]isoquino[2,1-a]perimidin-14-one
- Cas Number:
- 6829-22-7
- Molecular formula:
- C22H12N2O
- IUPAC Name:
- 14H-benz[4,5]isoquino[2,1-a]perimidin-14-one
- Test material form:
- other: red powder
- Details on test material:
- no further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: males 9 weeks; females 14 weeks
- Weight at study initiation: males ca 158 g; females ca 164 g
- Fasting period before study: 16 hours
- Housing: in groups of 5 per sex
- Diet : fasting post administration for 4 hours then ad libitum
- Water ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22
- Humidity (%): 50
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Lutrol
- Details on oral exposure:
- Single oral application by gavage of 5000 mg/kg bw to male and female rats
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 male and 5 female rats/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: several times on the day of administration and then twice daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathological evaluation - Statistics:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: limit test: no animal died, no clinical signs, growth not retarded
- Mortality:
- no rat died
- Clinical signs:
- other: no clinical signs were observed
- Gross pathology:
- no gross pathological findings
Any other information on results incl. tables
After single administration of 5000 mg/kg no clinical signs of systemic poisoning were observed.
No deaths occurred.
The male and female rats sacrificed at the end of the study did not show any noticeable gross pathological findings.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No animal died. Thus the LD50 is greater than 5000 mg/kg bw/day.
- Executive summary:
In a study according to the respective guideline 5 male and 5 female Wistar rats were given 5000 mg MACROLEX Red CA 51038 (CAS no 6829-22-7)/kg bw dissolved in lutrol and observed for mortality and clinical signs and body weight development over a period of 14 days. No animal died or displayed clinical signs. Necropsy revealed no gross pathological changes. Thus the LD50 is considered to be greater than 5000 mg/kg bw/day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.