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EC number: 283-381-8 | CAS number: 84604-96-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Three invitro studies are reviewed.
No mutations were observed in bacterial strains, no cytogenicity was observed in human lymphocytes with respect to sister chromosome abberrations, and finally no cytotoxicty was observed in human lung fibroblasts
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 1- June 1983
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Ames test 5 Salmonella strains and triplicate plates
- Version / remarks:
- oecd short term tox group - no Ecoli strain
- Deviations:
- no
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
- Specific details on test material used for the study:
- Purity 98%
BN 2152
stored at room temperature - Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- with S-9 mix ( 2 aminoanthracene for strains TA1535, TA1537, TA1538, TA98 and TA100
- Test concentrations with justification for top dose:
- On each bacterial strain, four concentrations of test substance was assessed. he highest concentration will usually be 0.05g of test substnce dissolved in 1.0ml of solvent. Three 10 fld serial dilutions of the top concentrations will also be tested.
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- 9-aminoacridine
- sodium azide
- other: 2 aminoanthracene
- Key result
- Species / strain:
- S. typhimurium TA 1535
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not determined
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- Zinc Diisononyldithiocarbamate was non toxic towards the tester strains. Therefore the 5000 microgramme/plate was chosen as the top dose level in mutation tests.
The mean number of revertant colonies, together with the individual plate counts for Zinc Diisononyldithiocarbamate obtained in the first mutation test with tester strains TA 1535, TA1538, TA98 anmd TA100 are shown in tbale 2 and the sterility and positive controls in table 3.
No substantial increases int he revertant colony numbers of any of the five strains were observed following treatment with Zinc Diisononyldithiocarbamate at any dose level, either in presence or absence of liver microsomal fraction (S9 mix) - Conclusions:
- No evidence of mutagneic potential of test item was obtained in this bacterial test system.
- Endpoint:
- in vitro cytogenicity / micronucleus study
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 473 (In Vitro Mammalian Chromosome Aberration Test)
- Version / remarks:
- evaluated sister chromatid exchange, chromosome aberrations, micro nulcie, mitotic index and cell cycle distribution. The functionality of the tests was ensured by suitable positive controls.
- Principles of method if other than guideline:
- - Principle of test:
- Short description of test conditions: Zinc diisononyldithiocarbamates at three concentrations was investigated cytogenetically on lymph cell cultures from various probands. The incubation period, with external activation was 21h. In the presence of an external metabolic activating system ( acroclor - induced rat liver microsomes) the peroid of incubation was 1h and 2h
- Parameters analysed / observed:evaluated sister chromatid exchange, chromosome aberrations, micro nulcie, mitotic index and cell cycle distribution. The functionality of the tests was ensured by suitable positive controls. - GLP compliance:
- no
- Type of assay:
- other: in vitro cytogenic mutagenicity study in human blood lymphocytes to detect chromosome aberration, sister chromatid exchanges, miconulcei, mitosis index and cell cycle distribution
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- mitomycin C
- Statistics:
- t test used
- Key result
- Species / strain:
- lymphocytes:
- Metabolic activation:
- with and without
- Genotoxicity:
- not determined
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not valid
- Positive controls validity:
- valid
- Remarks on result:
- not measured/tested
- Conclusions:
- Under all test conditions the results give no indication of a cytogenetically detectable mutagenic effect due to test item
- Endpoint:
- genetic toxicity in vitro, other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- aug 1994
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other: BS 5736 Part 10 (1988)
- Version / remarks:
- evaluation of medical devices for biological hazards
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of assay:
- other: Cytoxicity to Embryonic human lung fibroblasts
- Specific details on test material used for the study:
- BN 93102
date tested 31 aug 1994 - Species / strain / cell type:
- mammalian cell line, other: lung fibroblasts
- Details on mammalian cell type (if applicable):
- MRC 5 embryonic human lung cells
- Test concentrations with justification for top dose:
- test sample was prepared as 10mg/ml suspension which was double diluted with vigorous mixing down to 1/16th prior to incubation in culture media for 24 hours
top dose was 1% w/v concentratin - Rationale for test conditions:
- Positive control discs - containing 0.57% dibutyl tin dimaleate
negative control - silicone rubber - Evaluation criteria:
- by microscopic examination of fixed and stained cultures.
Criteria
0 - no cells showing damage
1 - up to 25% of cells showing damage
2- 25-50% of cells showing damage
3. 50-75% of cells showing damage
4. > 75% of celss showing damage - Conclusions:
- No cytotoxic effects were observed in all dilutions including neat test item ( 1%w/v)
Referenceopen allclose all
SCE analysis: 50 metaphases of secnd cell cycle were assessed & SCE number determined
CA rates: 50 metaphases assessed.
Miconuclei rates: depending upon the scatter of values, 3 - 4 counts each of 1000 cells
Mitosis index, depending upon the scatter of values, 3 - 4 counts each of 1000 cells
Cell cycle distribution
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Justification for classification or non-classification
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