Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 259-583-7 | CAS number: 55302-96-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
No study adressing the fertility endpoint is available for 2-Methyl-5-hydroxyethylaminophenol. However, the results obtained in the 90 days oral repeated dose toxicity study did not show any significant adverse effect on male and female reproductive organs (testes, prostate, seminal vesicles, epididymides, mammary glands, ovaries, uterus and vagina) based on the organ weights, necropsy and micorscopic evaluation findings.
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Effects on developmental toxicity
Description of key information
Based on the results of the key study (OECD Guideline 414, GLP, Klimisch 1), the NOAEL oral route (gavage) of maternal toxicity and embryo-/foetotoxicity in rats were both 1000 mg/kg bw/day (highest dose tested).
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Toxicity to reproduction: other studies
Additional information
Toxicity to reproduction:
No study adressing the fertility endpoint is available for 2-Methyl-5-hydroxyethylaminophenol.However, the results obtained in the 90 days oral repeated dose toxicity study did not show any significant adverse effect on male and female reproductive organs (testes, prostate, seminal vesicles, epididymides, mammary glands, ovaries, uterus and vagina) based on the organ weights, necropsy and micorscopic evaluation findings.
Developmental toxicity / teratogenicity:
Two Embryo-foetal developmental toxicity studies by the oral route in the rat are available (one key recent and guideline study with a Klimisch 1 quotation and one non-guideline ancient supporting study with a Klimisch 2 quotation). The results of both studies are concordant. In the key study (OECD Guideline 414, GLP, Klimisch 1), 2-Methyl-5-hydroxyethylaminophenol was administred to female Sprague-Dawley rats by gavage at the doses of 100, 300 and 1000 mg/kg bw from day 6 to 19 of gestation. The results of this study showed that 2-Methyl-5-hydroxyethylaminophenol was well tolerated at all the tested doses, and that no signs of toxicity were noted in the pregnant females, on the embryofetal development or on the growth in utero at any dose-level. Based on the results of this key study, the NOAEL of maternal toxicity and embryo-/foetotoxicity in rats were both 1000 mg/kg bw/day.
Justification for classification or non-classification
The available data do not suggest that 2-Methyl-5-hydroxyethylaminophenol should be classified for reproductive toxicity.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.