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EC number: 248-469-2 | CAS number: 27458-92-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No skin sensitization was observed for Isotridecanol and two similar branched alcohols: Isononanol and Isodecanol
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- see justification attached to chapter 13
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Remarks on result:
- no indication of skin sensitisation
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Since data for the registered substance are limited, data from related branched alcohols were additionally included in the IUCLID dossier. A detailed read across justification is attached to IUCLID chapter 13.
CAS 25339-17-7 (Iso-decanol)
In a modified Draize test, Sharp et al. (1978) injected 10 guinea pigs with 2.5 times the concentration that gave barely perceptible irritation in a preliminary irritation test, i.e., 0.25%, of isodecanol. Two weeks later, the animals were challenged intradermally with 0.1% and topically with 10% (a concentration that does not cause irritation). With the exception of the induction treatment, control animals were treated the same. Isodecanol did not cause skin sensitization in this assay.
CAS 27458-94-2 (Isononanol)
A Buehler test was performed with Isononanol by BASF in 2008. 0.5 ml of undiluted test substance was applied under occlusive dressing to each of the 20 guinea pigs in the test group for 6h. The application was repeated three times at weekly intervals at the same skin site. Fourteen days after the last induction treatment, all animals including the 10 control animals were dermally exposed to 0.5 ml of undiluted test substance under occlusive conditions for 6h. Skin reactions were read after 24 and 48h. No skin reaction was observed in any of the 10 control and 20 test animals. A routinely performed positive control with Alpha-Hexylcinnamaldehyde showed the expected results. Consequently, Isononanol did not cause skin sensitization in this assay.
CAS 27458-92-0 (Isotridecanol, registered substance)
Data for Isotridecanol are only available from a secondary source (Bibra 1988) and contain only a limited amount of information, but they confirm the absence of skin sensitizing properties determined with the related branched alcohols. An intracutaneous test was conducted with 70% branched chain primary isomers of Tridecanol and 30% Pentadecanol as test substance. In a group of 20 guinea pigs an unspecified number of intradermal injections of a 1% mixture of the test substance in liquid paraffin were followed 1 week later by the topical application (probably covered, 48h) of a similar 5% solution. A topical challenge with 0.1% of the same mixture in liquid paraffin (probably covered, 48 h) given 2 weeks later produced no reactions.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
No skin sensitization was observed for Isotridecanol and two similar branched alcohols: Isononanol and Isodecanol. Consequently, no classification according to 1272/2008/EC (CLP) criteria is required.
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