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Diss Factsheets
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EC number: 204-516-9 | CAS number: 122-03-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- 4-isopropylbenzaldehyde
- EC Number:
- 204-516-9
- EC Name:
- 4-isopropylbenzaldehyde
- Cas Number:
- 122-03-2
- Molecular formula:
- C10H12O
- IUPAC Name:
- 4-(propan-2-yl)benzaldehyde
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- LLNA: 355 (Cuminic Aldehyde)
Batch: 2080618
Supplier: Soda Aromatic Co., Ltd.
Clear colourless liquid
Storage: 2-8'C, refridgerated
Composition: Certification of analysis in appendix III of the report.
20 uCi of 3H-thymidine in sterile saline.
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA:J
- Sex:
- female
- Details on test animals and environmental conditions:
- Housed 5 per cage.
12 hour light and dark cycle.
Food and water ad litibum.
Acclimatised for a minimum of 6 days.
Study design: in vivo (LLNA)
- No. of animals per dose:
- 5
- Details on study design:
- Groups of 5 CBA/J female mice were treated on the dorsal surface of both ears once per day for 3 days.
On day 6, the mice were injected with 20 uCi of 3H-thymidine in sterile saline.
Five hours later the mice were euthanised and the draining auricular lymh nodes removed.
The lymph nodes cells were pooled then prciptated with 5% trichloroacetic acid and the pellets counted in a beta-scintillation counter to determine incorporation of the 3H-thymidine.
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Key result
- Parameter:
- SI
- Value:
- 2
- Variability:
- All animals per group no reactions.
- Test group / Remarks:
- No clinical observations
- Parameter:
- SI
- Value:
- 1.1
- Variability:
- All animals per group no reactions.
- Test group / Remarks:
- No clinical observations
- Parameter:
- SI
- Value:
- 1.3
- Variability:
- All animals per group no reactions.
- Test group / Remarks:
- No clinical observations
- Parameter:
- SI
- Value:
- 1.5
- Variability:
- All animals per group no reactions.
- Test group / Remarks:
- No clinical observations
- Parameter:
- SI
- Value:
- 2
- Variability:
- All animals per group no reactions.
- Test group / Remarks:
- No clinical observations
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the criteria of the OECD 429 test guidline, no dose levels gave an SI score of greater than 3. Therefore, cuminic aldehyde does not fufill the criteria as a skin sensitiser.
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