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EC number: 214-478-5 | CAS number: 1132-61-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- ANALOGUE APPROACH JUSTIFICATION
Please refer to the attached read-across justification in section 13 - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 080 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Duration:
- 3 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 080 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC10
- Effect conc.:
- > 1 080 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
Reference
Description of key information
In a limit test with the nominal concentration of 1080 mg/L no inhibitory effect of the read-across substance was observed as compared to the blank control after 3 hours of incubation (reference 6.1.7-1).
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 080 mg/L
- EC10 or NOEC for microorganisms:
- 1 080 mg/L
Additional information
No study data with the test item is available for toxicity to microorganisms. Therefore, a read-across to the read-across substance with a very similar chemical structure and comparable physico-chemical parameters is used to evaluate the potential for toxicity to microorganisms of the test item.
The purpose of the 3 hour test was to evaluate the influence of the read-across source substance on the activity of the activated sludge by measuring the respiration rate under defined conditions in a study according to OECD TG 209 under GLP conditions. The respiration rates (total, heterotrophic and nitrification oxygen uptake rates) of samples of activated sludge fed with synthetic sewage were measured in an enclosed cell containing an oxygen electrode after a contact time of 3 hours. A preliminary test was performed to estimate the range of concentrations of the test item needed in the definite (main) test for determining the inhibition of oxygen consumption. In the preliminary test of this study, the test item was investigated at the nominal concentrations of 10.8; 108 and 1080 mg/L. These test item concentrations were chosen taking into account a correction for the water content of the test item. In parallel with the test item treatments 3,5-Dichlorophenol was used as positive reference control; furthermore blank (inoculum) control, nitrification controls and abiotic controls were investigated. Based on the absence of any inhibitory effect in the preliminary experiment, the test item was investigated at the limit concentration of nominal 1080 mg/L in the main test. Similarly to the preliminary test, defined amounts of the test item were added directly into the test vessels. In parallel with the test item treatments, 3,5-Dichlorophenol was used as positive reference control at concentration levels of 2, 7 and 24.5 mg/L; furthermore blank (inoculum) control and nitrification controls were investigated. The definite test was performed without abiotic controls, based on the results of the preliminary test where abiotic controls were tested at the test item concentration of 1080 mg/L and no remarkable abiotic oxygen consumption was noticed. In accordance to the preliminary experiment, the test item does not adversely affect the pH within the test system; therefore, the main test was performed without additional pH adjustment. All validity criteria of the study were met. The observed oxygen consumption rates and consequently the specific respiration rates in the examined test item (limit) concentration remained in the range of the blank controls (the average specific respiration rate at 1080 mg/L: 37.13 mg O2/gh), no remarkable inhibitory effect of the test item was observed. The obtained 1.17 % inhibition was considered as being within the range of biological variability of the applied test system. The specific respiration rates at the examined test item concentration of 1080 mg/L were compared with the blank control values using 2-Sample T-test (α = 0.05). No statistical significant differences were noticed in the comparison of blank control and test item treated groups. Under the test conditions, the EC10 and EC50 values of test item were determined as higher than 1080 mg/L. Based on the statistical evaluation in this test the NOEC was 1080 mg/L. In conclusion this study demonstrated the absence of inhibition of oxygen consumption by the test item up to and including the limit concentration of 1080 mg/L.
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