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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1991
Report date:
1991

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: US. 52 FR 42964, 49 CFR 173.136(a)
Principles of method if other than guideline:
Test material is applied to the shaved skin of rabbits for 3 min, 60 min and 4 hr, and then removed and the site is rinsed. Evaluations of the site are made at 30-60 min and 48 h after exposure. Skin erythema, edema and corrosion are assessed.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
3-methylpyridine
EC Number:
203-636-9
EC Name:
3-methylpyridine
Cas Number:
108-99-6
Molecular formula:
C6H7N
IUPAC Name:
3-methylpyridine

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
0.5 ml/site, undiluted
Duration of treatment / exposure:
3 min, 60 min and 4 h.
Observation period:
30-60 min, and 48 h.
Number of animals:
6 rabbits per group
Details on study design:
Corrosion is defined as irreversible alteration or destruction to the tissue in at least 3 of the animals. Necrosis is defined as ulceration or necrosis of the skin.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: necrosis
Basis:
mean
Time point:
other: 3 min
Score:
0
Max. score:
6
Reversibility:
other: not applicable
Remarks on result:
other: no indication of corrosion
Remarks:
Corrosion study at 3 min, 60 min, 4 h
Irritation parameter:
other: necrosis
Basis:
mean
Time point:
other: 60 min
Score:
1
Max. score:
6
Reversibility:
not reversible
Remarks on result:
other: in 1 of 6 animals in this group
Remarks:
Qualitative scoring: presence/absence of ulceration/necrosis. Corrosion study at 3 m, 60 min and 4 h
Irritation parameter:
other: necrosis
Basis:
mean
Time point:
other: 4 h
Score:
4
Max. score:
6
Reversibility:
not reversible
Remarks on result:
other: in 3 of 6 animals
Remarks:
Qualitative scoring: presence/absence of ulceration/necrosis. Corrosion study at 3 m, 60 m and 4 h

Any other information on results incl. tables

No effects after a 3 minute exposure.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information Criteria used for interpretation of results: other: U.S. Department of Transportation
Conclusions:
3-Methylpyridine was tested for skin corrosion using U.S. Department of Transportation guidelines. The substance was corrosive to the skin of rabbits after a 4 h occlusive exposure.