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EC number: 219-948-3 | CAS number: 2580-77-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted between 6 March 1998 and 17 May 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Sponsor's identification: BHES-100X
Batch number: 1A0110
Date received: 20 January 1998
Storage conditions: room temperature in the dark - Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Aliquots of the sample solutions were taken from the flasks at various times and the pH of each solution recorded.
The concentration of the sample solution was determined by HPLC.
Duplicate aliquots (A and 8) of sample solutions were diluted by a factor of two using acetonitrile.
Duplicate standard solutions of test material were prepared in acetonitrile:buffer (1: 1 v/v) at a nominal concentration of 500 mg/I. - Buffers:
- See table in 'any other information on metrials and methods' section
- Details on test conditions:
- Preparation of samples
Sample solutions were prepared in stoppered glass flasks at a nominal concentration
of 1 g/I in the three buffer solutions.
The solutions were shielded from light.
Preliminary test
Sample solutions at pH 4, 7 and 9 were maintained at 50.0 ± 0.5 °C for a period
of 120 hours. - Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 1 g/L
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 1 g/L
- Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 1 g/L
- Positive controls:
- no
- Negative controls:
- no
- Preliminary study:
- After incubation at 50 °C for 120 hrs > 96% BHES-100X was recovered at pH 4, 7 and 9.
- Transformation products:
- not measured
- % Recovery:
- 101
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 97.5
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 96.9
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 120 h
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The estimated half-lives at 25 °C of BHES-100X are greater than 1 year a pH 4, 7 and 9.
- Executive summary:
Assessment of hydrolytic stability was carried out using Method 111 of the OECD Guidelines for the Testing of Chemicals, 12 May 1981. The results are shown in the table below.
pH
Estimated half-life at 25°C
4
Greater than 1 year
7
Greater than 1 year
9
Greater than 1 year
Reference
The following tables show the test material concentrations at the given timepoints.
pH4 at 50 ± 0.5 °C
Time (hours) |
0 |
2.4 |
120 |
Concentration (g/l) |
1.01 |
1.01 |
1.02 |
% of initial |
100 |
99.9 |
101 |
Result: Less than 10% hydrolysis after 5 days at 50°C, equivalent to a half-life greater than 1 year at 25°C.
pH7 at 50 ± 0.5°C
Time (hours) |
0 |
2.4 |
120 |
Concentration (g/l) |
1.07 |
1.04 |
1.04 |
% of initial |
100 |
97.6 |
97.5 |
Result: Less than 10% hydrolysis after 5 days at 50°C, equivalent to a half-life greater than 1 year at 25°C.
pH9 at 50 ± 0.5°C
Time (hours) |
0 |
2.4 |
120 |
Concentration (g/l) |
1.03 |
1.02 |
0.999 |
% of initial |
100 |
98.9 |
96.9 |
Result: Less than 10% hydrolysis after 5 days at 50°C, equivalent to a half-life greater than 1 year at 25°C.
Description of key information
The estimated half-lives at 25 °C of BHES-100X are greater than 1 year a pH 4, 7 and 9.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
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