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EC number: 224-623-4 | CAS number: 4430-31-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reliability has been presented as 2 because similar to OECD Guideline protocol has been followed but not GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- no details on test material (purity not indicated), no details on test animals and environmental conditions, observation period unknown (only until day 5 included in report).
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Octahydro-2H-1-benzopyran-2-one
- EC Number:
- 224-623-4
- EC Name:
- Octahydro-2H-1-benzopyran-2-one
- Cas Number:
- 4430-31-3
- Molecular formula:
- C9H14O2
- IUPAC Name:
- octahydro-2H-1-benzopyran-2-one
- Test material form:
- liquid
1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
No details.
ENVIRONMENTAL CONDITIONS
No details.
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No details.
- Doses:
- 1730, 2470, 3510 and 5000 mg/kg bw
- No. of animals per sex per dose:
- 1730 mg/kg bw: total 20 (no sex specified)
2470, 3510 and 5000 mg/kg bw: 10 (no sex specified) - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 5 days
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 900 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 600 - 5 900
- Mortality:
- See "any other information results"
- Clinical signs:
- other: 1730 mg/kg bw: Lethargy, chromorhynorrhea, piloerection, ptosis and diarrhea. 2470 mg/kg bw: Lethargy and flaccid muscle tone. 3510 mg/kg bw: Lethargy, chromorhynorrhea and piloerection. 5000 mg/kg bw: Lethargy, chromorhynorrhea, piloerection, ataxia, red
Any other information on results incl. tables
Deaths per day after exposure to Bicyclononalactone
Dose mg/kg |
Deaths/day |
total |
1730 |
3/0, 1/1, 1/2, 1/5 |
6/20 |
2470 |
1/0, 2/1 |
3/10 |
3510 |
2/0, 1/1, 1/4 |
4/10 |
5000 |
3/0, 3/1 |
6/10 |
Necropsy observations after exposure to Bicyclononalactone
No. of rats | ||||
Doses mg/kg bw | 1730 | 2470 | 3510 | 5000 |
Normal | 8 | 2 | 1 | |
Cannabalized | 2 | |||
Exudate, nose/mouth, red | 2 | 3 | 2 | |
Exudate, nose/mouth, yellow | 1 | 1 | 3 | |
Exudate, anogenital, brown | 1 | |||
Exudate, anogenital, yellow | 2 | |||
Exudate, nose/mouth, clear | 1 | 2 | ||
Intestines, areas red | ||||
Intestines, areas yellow | 4 | 4 | 1 | 9 |
Intestines, bloated | 1 | |||
Stomach, areas red | 1 | 1 | ||
Liver dark | 8 | 2 | 4 | |
Liver mottled | 1 | 6 | 2 | |
Lungs dark | 1 | 3 | 2 | 4 |
Lungs areas dark | 1 | 3 | 2 | |
Consolidation of left lung * | 1 | |||
Kidney dark | 9 | 3 | 2 | 4 |
Kidney mottled | 1 | 4 | ||
Spleen dark | 2 | |||
Spleen large | 2 | 4 | ||
Spleen, tip darker than normal | 1 | |||
Bladder, contained blood | 1 | 2 |
* Hardened texture to lung tissue w/ yellowish nodules troughout.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not acute harmful.
- Remarks:
- According to Regulation (EC) No. 1272/2008 and its amendments.
- Conclusions:
- An LD50 of 3900 mg/kg bw was obtained in the acute oral toxicity study with rats. According to GHS the substance needs to be classified for acute oral toxicity category 5 and labelled with H103: May be harmful if swallowed.
- Executive summary:
In an acute oral toxicity study 4 groups of 10 rats were orally exposed to 1730, 2470, 3510 and 5000 mg/kg bw of the substance. The rats were observed for signs of toxicity and pharmacological effects for a period of 5 days. Deaths occurred on day 0, 1, 2, 4 and 5. Lethargy was seen at all levels, other clinical signs were chromorhynorrhea, piloerection, ataxia, red exudate, ptosis, diarrhea, falccid muscle tone and anogenital.
Based on the results, an LD50 of 3900 mg/kg bw was obtained in the acute oral toxicity study with rats.
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