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EC number: 272-599-9 | CAS number: 68892-13-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 11 October 2016 to 25 October 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- April 2014
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- May 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.2120 (Hydrolysis of Parent and Degradates as a Function of pH at 25°C)
- Version / remarks:
- October 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- The test item was heated to 40-50°C until complete melting of the crystallized part before being used in liquid form.
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Buffers:
- - pH: 4,7 and 9
- Type and final molarity of buffer:
Acetate buffer 0.01 M
Phosphate buffer 0.01 M
Borate buffer 0.01M
- Composition of buffer:
Acetate buffer: 16.7% of 0.01M sodium acetate, 83.3% of acetic acid in water and 0.0009% (w/v) sodium azide
Phosphate buffer:0.01 M potassium di-hydrogen-phosphate solution in water adjusted to pH 7 using 1N sodium hydroxide. Buffer contained 0.0009% (w/v) sodium azide.
Borate buffer:0.01 M potassium di-hydrogen-phosphate solution in water adjusted to pH 7 using 1N sodium hydroxide. Buffer contained 0.0009% (w/v) sodium azide. - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: sterile vessel
- Lighting: no light during the test
- Measures taken to avoid photolytic effects: test performed in the dark
- Measures to exclude oxygen: nitrogen gas
- Is there any indication of the test material adsorbing to the walls of the test apparatus? No
TEST MEDIUM
- Kind and purity of water: tap water purified by a Milli-Q water purification system
- Preparation of test medium: Test item solution spiked in setrile buffers solution using a spiking solution in acetonitrile
- Renewal of test solution: No
- Identity and concentration of co-solvent: Acetonitrile - Duration:
- 21.2 d
- pH:
- 4
- Temp.:
- 20 °C
- Initial conc. measured:
- >= 112 - <= 120 µg/L
- Duration:
- 8.1 d
- pH:
- 4
- Temp.:
- 40 °C
- Initial conc. measured:
- >= 107 - <= 117 µg/L
- Duration:
- 5.1 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 97.3 - <= 100 µg/L
- Duration:
- 21.2 d
- pH:
- 7
- Temp.:
- 20 °C
- Initial conc. measured:
- >= 113 - <= 125 µg/L
- Duration:
- 4 d
- pH:
- 7
- Temp.:
- 40 °C
- Initial conc. measured:
- >= 119 - <= 123 µg/L
- Duration:
- 5.1 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 107 - <= 109 µg/L
- Duration:
- 14.1 d
- pH:
- 9
- Temp.:
- 20 °C
- Initial conc. measured:
- >= 97.5 - <= 111 µg/L
- Duration:
- 2.1 d
- pH:
- 9
- Temp.:
- 40 °C
- Initial conc. measured:
- >= 114 - <= 115 µg/L
- Duration:
- 1 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 97.2 - <= 99.1 µg/L
- Number of replicates:
- 2 replicates for each pH-temperature conditions
- Statistical methods:
- Nth-Order Rate or Intermediate Order Rate Equation (IORE) model to determine DT50
- Preliminary study:
- At pH 4, pH 7 and pH 9, a degree of hydrolysis of ≥ 10% was observed after 5 days.
- Test performance:
- The main test was performed at pH 4, 7 and 9 at 20, 40 and 50°C.
- Transformation products:
- not measured
- % Recovery:
- > 74 - < 80
- pH:
- 4
- Temp.:
- 20 °C
- Duration:
- 0 s
- % Recovery:
- > 72 - < 78
- pH:
- 4
- Temp.:
- 40 °C
- Duration:
- 0 s
- % Recovery:
- > 65 - < 67
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 0 s
- % Recovery:
- > 75 - < 83
- pH:
- 7
- Temp.:
- 20 °C
- Duration:
- 0 s
- % Recovery:
- > 79 - < 82
- pH:
- 7
- Temp.:
- 40 °C
- Duration:
- 0 s
- % Recovery:
- > 71 - < 73
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 0 s
- % Recovery:
- > 65 - < 74
- pH:
- 9
- Temp.:
- 20 °C
- Duration:
- 0 s
- % Recovery:
- > 76 - < 77
- pH:
- 9
- Temp.:
- 40 °C
- Duration:
- 0 s
- % Recovery:
- > 65 - < 66
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 0 s
- Key result
- pH:
- 4
- Temp.:
- 20 °C
- DT50:
- 21.1 h
- Type:
- other: Intermediate Order Rate
- Key result
- pH:
- 4
- Temp.:
- 40 °C
- DT50:
- 1.62 h
- Type:
- other: Intermediate Order Rate
- Key result
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- 0.576 h
- Type:
- other: Intermediate Order Rate
- Key result
- pH:
- 7
- Temp.:
- 20 °C
- DT50:
- 9.61 h
- Type:
- other: Intermediate Order Rate
- Key result
- pH:
- 7
- Temp.:
- 40 °C
- DT50:
- 0.798 h
- Type:
- other: Intermediate Order Rate
- Key result
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- 0.386 h
- Type:
- other: Intermediate Order Rate
- Key result
- pH:
- 9
- Temp.:
- 20 °C
- DT50:
- 51.7 h
- Type:
- other: Intermediate Order Rate
- Key result
- pH:
- 9
- Temp.:
- 40 °C
- DT50:
- 1.84 h
- Type:
- other: Intermediate Order Rate
- Key result
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- 0.752 h
- Type:
- other: Intermediate Order Rate
- Details on results:
- TEST CONDITIONS
- pH, sterility, temperature, and other experimental conditions maintained throughout the study: Yes
- Conclusions:
- The test item is hydrolysed at pH4, 7 and 9 for all the temperature tested (20, 40 and 50°C).
- Executive summary:
The behavior of the test item regarding hydrolysis was determined according to recognised guideline and under GLP.
No deviation from the guideline was observed during the study.
The disappearance time 50 (DT50) were calculated according to the Nth-Order Rate or Intermediate Order Rate Equation (IORE) model using Computer Aided Kinetic Evaluation (CAKE) Version 3.3.
The DT50 are detailed in the table below:
pH Temperature (°C) DT50 (Hours) 4 20 21.1 4 40 1.62 4 50 0.576 7 20 9.61 7 40 0.789 7 50 0.386 9 20 51.7 9 40 1.84 9 50 0.752
Reference
Description of key information
The hydrolysis of the test item was determined in experimental key study (Klimisch validity one, according to recognised guidelines).
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 9.61 h
- at the temperature of:
- 20 °C
Additional information
The disappearance time 50 (DT50) were calculated according to the Nth-Order Rate or Intermediate Order Rate Equation (IORE) model using Computer Aided Kinetic Evaluation (CAKE) Version 3.3.
The DT50 are detailed in the table below:
pH | Temperature (°C) | DT50 (Hours) |
4 | 20 | 21.1 |
4 | 40 | 1.62 |
4 | 50 | 0.576 |
7 | 20 | 9.61 |
7 | 40 | 0.789 |
7 | 50 | 0.386 |
9 | 20 | 51.7 |
9 | 40 | 1.84 |
9 | 50 | 0.752 |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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