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EC number: 233-397-6 | CAS number: 10139-58-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In an OECD Test Guideline 423 study, to GLP, the acute oral LD50 value of rhodium trinitrate hydrate was determined to range between 200 and 2000 mg/kg bw following gavage administration in rats (van Huygevoort, 2003a).
No relevant acute dermal or inhalation toxicity data were identified, or are required at this tonnage.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 December 2002 - 22 January 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Conducted according to GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
- Species:
- rat
- Strain:
- other: Wistar strain Crl:(WI) BR (Outbred, SPF-Quality)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland, Sulzfeld, Germany
- Age at study initiation: young adult animals, approximately 8 weeks old
- Weight at study initiation: 161-258 g
- Fasting period before study: overnight (for a maximum of 20 hrs) prior to dosing until 3-4 hrs after administration of test substance
- Housing: 3 animals/sex/cage in Macrolon cages (type IV; height 18 cm)
- Diet (e.g. ad libitum): ad libitum standard pelleted laboratory animal diet (from Altromin, code VRF-1, Lage Germany)
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21±3ºC
- Humidity (%): 30-70%
- Air changes (per hr): approx. 15 air changes/hr
- Photoperiod (hrs dark / hrs light): 12 hrs artificial fluorescent light and 12 hrs dark/day
IN-LIFE DATES: From: To: - Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
VEHICLE
- Concentration in vehicle:
- Amount of vehicle (if gavage):
- Justification for choice of vehicle: selected based on trial formulations
- Lot/batch no. (if required):
- Purity:
MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg
DOSAGE PREPARATION (if unusual):
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: no data- Doses:
- 200 and 2000 mg/kg bw.
- No. of animals per sex per dose:
- Each dose group consisted of 3 animals/sex (females were nulliparous and non-pregnant).
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations for mortality/viablility were made twice daily. Body weights were recorded the day before administration, and weekly after dosing.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, macroscopic post mortem examination.- Statistics:
- No statistical analysis was performed.
- Sex:
- female
- Dose descriptor:
- approximate LD50
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Mortality:
- No male or female rats died over the study period at 200 mg/kg bw. At 2000 mg/kg bw all three female rats in the treatment group were killed in extremis on day 2 after treatment.
- Clinical signs:
- other: Females at 200 mg/kg bw dose level: hunched posture, piloerrection Males at 200 mg/kg bw: hunched posture Females at 2000 mg/kg bw: lethargy, hunched posture, uncoordinated movements, swelling, piloerection, yellow staining (genital region), yellow disc
- Gross pathology:
- No abnormalities were observed in the surviving male and female animals of the 200 mg/kg bw treatment groups. Examination of the three female rats treated at 2000 mg/kg bw revealed abnormalities of the stomach (hardened wall and content, dark red discolouration fore stomach, distended with gas).
- Other findings:
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- Organ weights: no data
- Histopathology: no data
- Potential target organs:
- Other observations: - Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- In a guideline study, to GLP, the acute oral LD50 value of rhodium trinitrate hydrate was determined to range between 200 and 2000 mg/kg bw following gavage administration in rats.
- Executive summary:
In an OECD Test Guideline 423 study, to GLP, rhodium trinitrate hydrate was studied for acute toxicity after single oral administration in Wistar rats. The test substance was administered by oral stomach tube at a dose of 200 mg/kg bw to groups of rats (3/sex). A further group of three females received a dose of 2000 mg/kg bw.
No mortality was observed at the 200 mg/kg bw dose level. The three females treated at 2000 mg/kg bw were killed in extremis one day following treatment. Hunched posture (males and females) and piloerection (females only) were observed at the lower dose. Numerous clinical signs were observed in the 2000 mg/kg bw treated females, including: lethargy, hunched posture, uncoordinated movements, swelling, piloerection, yellow staining (genital region), yellow discolouration (urine), hypothermia, rales, pale, ptosis, laboured respiration, orange staining (lower mandible), orange staining (forelegs), and salivation. Surviving animals recovered within one or two days of treatment. The growth shown by the surviving animals over the study period was considered by the author of the report to be normal. Macroscopic post mortem examination of the three female rats from the 2000 mg/kg bw treatment group revealed abnormalities of the stomach (hardened wall and content, dark red discolouration fore stomach, distended with gas). No abnormalities were observed at macroscopic post mortem examination of the surviving animals from the 200 mg/kg bw treatment groups.
An acute oral LD50 value of >200 and < 2000 mg/kg bw was determined in male and female rats (van Huygevoort, 2003a). This is considered to approximate to a discriminating dose of 300 mg/kg bw. The adverse signs were typical of severe local gastrointestinal effects, rather than of systemic toxicity.
Based on the results of this study, rhodium trinitrate hydrate should be classified for acute oral toxicity (category 4) according to EU CLP criteria (EC 1272/2008).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 300 mg/kg bw
- Quality of whole database:
- Overall, good-quality database which meets REACH Standard Information Requirements.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No relevant acute toxicity human data were identified.
In an OECD Test Guideline 423 study, to GLP, rhodium trinitrate hydrate was studied for acute toxicity after single oral administration in Wistar rats. The test substance was administered by stomach tube at a dose of 200 mg/kg bw to groups of rats (3/sex).A further group of three females received a dose of 2000 mg/kg bw. No mortality was observed at the 200 mg/kg bw dose level. The three females treated at 2000 mg/kg bw were killed in extremis one day following treatment. Hunched posture (males and females) and piloerection (females only) were observed at the lower dose. Numerous clinical signs were observed in the 2000 mg/kg bw treated females, including: lethargy, hunched posture, uncoordinated movements, swelling, piloerection, yellow staining (genital region), yellow discolouration (urine), hypothermia, rales, pale, ptosis, laboured respiration, orange staining (lower mandible), orange staining (forelegs), and salivation. Surviving animals recovered within one or two days of treatment. The growth shown by the surviving animals over the study period was considered by the author of the report to be normal. Macroscopic post mortem examination of the three female rats from the 2000 mg/kg bw treatment group revealed abnormalities of the stomach (hardened wall and content, dark red discolouration fore stomach, distended with gas). No abnormalities were observed at macroscopic post mortem examination of the surviving animals from the 200 mg/kg bw treatment groups. An acute oral LD50 value of >200 and < 2000 mg/kg bw was determined in male and female rats (van Huygevoort, 2003a). This is considered to approximate to a discriminating dose of 300 mg/kg bw. The adverse signs were typical of severe local gastrointestinal effects, rather than of systemic toxicity.
No acute dermal or inhalation toxicity data were identified, or are required at this tonnage (1-10 tpa).
Justification for classification or non-classification
Based on the results of the available and reliable acute oral rat study, rhodium trinitrate hydrate should be classified for acute oral toxicity (category 4) according to EU CLP criteria (EC 1272/2008).
No evidence of specific target organ toxicity was noted. As such, classification for STOT-SE is not considered appropriate.
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