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EC number: 259-587-9 | CAS number: 55310-46-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No data are available on skin and eye irritating properties of isolated (anhydrous) sodium dibenzyldithiocarbamate. However, as the substance is manufactured and marketed by the registrant solely as a saturated (ca. 17%) aqueous solution, an exposure to pure substance is not expected to be possible. Therefore for the risk assessment purposes it is considered to be acceptable and in fact more relevant to use skin and eye irritation data on the substance as manufactured.
Sodium dibenzyldithiocarbamate (SBEC) in 16.9% aqueous solution was not irritating to rabbit skin in a GLP-compliant OECD 404 Guideline study. Results of GLP-compliant OECD 405 Guideline study indicated that the substance elicits risk of serious damage to eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
No data on skin and eye irritating properties of isolated (anhydrous) sodium dibenzyldithiocarbamate are available. However, the substance is solely manufactured and marketed by the registrant as a saturated aqueous solution (ca. 17% w/w) and it is not expected that exposure to pure substance is possible. Therefore for the risk assessment it is considered to be acceptable and in fact more relevant to use skin and eye irritation data on the substance as manufactured.
Skin-irritating properties of sodium dibenzyldithiocarbamate (SBEC) in 16.9% aqueous solution were studied in a GLP-compliant study with rabbits (Life Science Research Ltd, 1992b), performed according to OECD Guideline 404. Very slight or well defined erythema and very slight oedema were observed at the test sites of two rabbits during the fisrt 24 or 48 hours after bandange removal. Very slight erythema alone was evident at the 72 hours examination. The mean erythema and oedema scores for 3 animals, calculated for 24 + 48 + 72 hours were 0.9 and 0.47, respectively. Based on these results, sodium dibenzyldithiocarbamate in its marketed form is considered to be not irritating to rabbit skin. It should be noted that no information on skin irritating properties of the pure (anhydrous) substance can be derived from these results. One study on eye irritation with sodium dibenzyldithiocarbamate in i16.9% aqueous solution, performed in accordance with OECD Guideline 405 and under GLP, was available for assessment (Life Science Research Ltd, 1992c). Instillation of the test material caused a moderate initial pain response. A diffuse crimson-red appearance of the conjunctiva, very slight chemosis and a substantial discharge were evident throughout the first 72 hours following instillation. Slight opacity, covering up to the entire corneal surface, and iritis were observed at this time. At the end of the first week of observation, injection of the conjunctival blood vessels and slight corneal opacity persisted; the opacity resolved by the fourteenth day after treatment, but the conjunctival change persisted to termination. The average scores for corneal opacity, iritis, conjunctival redness and chemosis, calculated over all animals for 24 + 48 + 72 hours, were 1, 1, 2 and 1, respectively. Based on the persistence of ocular changes which lasted until the end of the observation period, the substance is considered to induce serious damage to eyes.
Effects on eye irritation: irritating
Justification for classification or non-classification
Based on the erythema and edema scores of 0.9 and 0.47 respectively, the substance in its marketed form (as ca. 17% aqueous solution) does not need to be classified as skin irritant, according to the EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Based on the persistence of the ocular changes (diffuse crimson-red appearance of conjuntiva) at the end of the observation period, the substance should be classified as causing risk of serious damage to eyes (Xi, R41) in accordance with EU Directive 67/548/EEC. In accordance with EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 it needs to be classified as Category 1, H318 (causes serious eye damage).
It should be stated that this classification and labeling are not applicable for the isolated substance; however, as the substance is solely manufactured and marketed as saturated (ca. 17%) aqueous solution, the classification as reported above is considered to be acceptable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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