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EC number: 223-296-5 | CAS number: 3811-73-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.022 mg/L
Additional information
See Tables 6.1.3.1, 6.1.3.2, 6.1.3.3, and 6.1.3.4 for summaries on the acute toxicity to invertebrates of sodium pyrithione and its metabolites.
Acute studies on invertebrates indicate that NaPT is toxic. The LC50values range from 0.022 to 0.15 mg NaPT/L.The lowest NOEC for these studies was 0.011 mg NaPT/L.
Further, acute toxicity studies in fish for the major metabolites indicate that the most toxic substance is Pyrithione disulphide with a NOEC of 0.006 mg/L, to daphnia magna. Pyrithione disulphide is very short lived in the environment and the most relevant degradant of NaPT is Pyridine sulphonic acid (PSA). The NOEC for PSA is 51.1 for the eastern oyster.
Table 6.1.3.1: Acute toxicity of NaPT to invertebrates
Guideline / |
Species |
Endpoint / |
Exposure |
Results [mg/L] |
Remarks |
Reference |
|||
|
design |
duration |
NOEC |
LC50 |
LC100 |
|
|||
OECD 202. |
Daphnia magna |
Immobilis-ation |
Static |
48 hours |
0.02 |
0.15 |
1.3 |
|
6.1.3.001 ESPTF 7041-201 Smith et al (1994)
|
U.S. EPA-FIFRA, Guideline 72-2
|
Daphnia magna |
Immobilis-ation |
Flow through |
48 hours |
0.011 |
0.022 |
>0.037 |
6.1.3.002 ESPTF 7041-202 Smith et al (1994) |
Table 6.1.3.2: Acute toxicity of Pyridine-N-oxide-2-sulfonic acid to invertebrates
Guideline / |
Species |
Endpoint / |
Exposure |
Results [mg/L] |
Remarks |
Reference |
|||
|
design |
duration |
NOEC |
LC50 |
EC50 |
|
|||
US EPA- 72-2
|
Daphnia magna |
Immobility and mortality
|
Flow-through |
48 hours |
127 |
|
>127 |
|
6.1.3.005 EZPTF 7041-211 Ward TJ, Kowalski PL, Boeri RL (1994) |
US EPA – 72-3(b) |
Mysid
Mysidopsis bahia
|
Mortality |
Static |
96 hours |
32.2 |
71.3 |
|
|
6.1.3.007 EZPTF 7041-214 Ward TJ, Kowalski PL, Boeri RL (1994 |
US EPA |
eastern oysterCrassostrea virginica |
Shell growth |
Flow-through |
96 hours |
35.6 |
|
99.2 |
6.1.3.014 EZPTF 7041-217 Boeri RL, Kowalski PL, Ward TJ (1994)
|
Table 6.1.3.3: Acute toxicity of Pyridine Sulphonic acid to invertebrates
Guideline / |
Species |
Endpoint / |
Exposure |
Results [mg/L] |
Remarks |
Reference |
|||
|
design |
duration |
NOEC |
LC50 |
EC50 |
|
|||
US EPA- 72-2
|
Daphnia magna |
Immobility and mortality
|
Flow-through |
48 hours |
122 |
|
>122 |
|
6.1.3.006 EZPTF 7041-212 Ward TJ, Kowalski PL, Boeri RL (1994) |
US EPA – 72-3(b) |
Mysid –
Mysidopsis bahia |
Mortality |
Flow-through |
96 hours |
51.9 |
71.6 |
|
6.1.3.008 EZPTF 7041-215 Ward TJ, Kowalski PL, Boeri RL (1994)
|
|
US EPA |
eastern oysterCrassostrea virginica |
Shell growth |
Flow-through |
96 hours |
51.1 |
85.6 |
|
Key study
|
6.1.3.009 EZPTF 7041-218 Boeri RL, Kowalski PL, Ward TJ (1994)
|
Table 6.1.3.4: Acute toxicity of 2,2’-(pyridyl-N-oxide) disulphide to invertebrates
Guideline / |
Species |
Endpoint / |
Exposure |
Results [mg/L] |
Remarks |
Reference |
|||
|
design |
duration |
NOEC |
LC50 |
EC50 |
|
|||
US EPA- 72-2
|
Daphnia magna |
Immobility and mortality
|
Flow-through |
48 hours |
0.006 |
|
0.013 |
6.1.3.011 EZPTF 7041-210 Ward TJ, Magazu JP, Boeri RL (1995) |
|
US EPA- 72-3(b) |
Mysidopsis bahia |
Mortality |
static |
96 hours |
0.004 |
0.0064 |
|
6.1.3.012 EZPTF 7041-213 Ward TJ, Magazu JP, Boeri RL (1995) |
|
US EPA – 72-3(c) |
eastern oysterCrassostrea virginica |
Shell growth |
Flow-through |
96 hours |
0.110 |
|
0.16 |
6.1.3.013 EZPTF 7041-216 Ward TJ, Magazu JP, Boeri RL (1995)
|
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