Registration Dossier
Registration Dossier
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EC number: 252-478-7 | CAS number: 35274-05-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no GLP but orocedure used was according to F. H.S. L. A (Federal Hazardous Substance Act)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Was done according to F. H.S. L. A (Federal Hazardous Substance Act) procedure
- GLP compliance:
- no
Test material
- Reference substance name:
- Hexadecyl lactate
- EC Number:
- 252-478-7
- EC Name:
- Hexadecyl lactate
- Cas Number:
- 35274-05-6
- Molecular formula:
- C19H38O3
- IUPAC Name:
- hexadecyl lactate
- Test material form:
- not specified
- Details on test material:
- mazola corn oil used as a diluent
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
Test system
- Vehicle:
- other: mazola corn oil
- Controls:
- no
- Amount / concentration applied:
- 0.1ml per eye
- Duration of treatment / exposure:
- 24h
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: Day 1-7 days
- Score:
- 0
- Reversibility:
- not specified
- Other effects:
- No other effect
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating at 0.1%
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The text compound did not elicit eye irritation.
- Executive summary:
The test compund did not elicit eye irritation even though there was numerical scoring point. The numerical scoring point was very low (maximum 2 out of 110), thus can be neglected.
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