Registration Dossier
Registration Dossier
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EC number: 944-550-8 | CAS number: -
Endpoint summary
Administrative data
Description of key information
No studies on the toxicity of Insulin DesB30 towards, algae, invertebrates and fish were available.
The aquatic toxicity of Insulin DesB30 is assumed to be similar to the source substance (S5) because of the high degree of structural similarity.
• Insulin DesB30 and the source substance belong to the same chemical categories: human insulins, polypeptides and proteins
• Insulin DesB30 and the source substancs are composed of polypeptide containing amino acids
Insulin DesB30 is predicted to have a toxicity to algae with NOEC, EC10 and EC50 (48h) of <0.25, 0.33 and > 7.23 mg/L
(geometric mean concentration) based on the results from the study with Insulin Human Methyl Ester.
No effects towards invertebrates was observed during the study with Insulin Human Methyl Ester (S5) and an EC10 and EC50 (48h) of >300 mg/L (nominal concentration) or > 30.1 mg/L (geom. mean) were determined.
No mortality to fish was observed during the study with Insulin Human Methyl Ester (S5) and the LC50 is therefore reported as > 3.6 mg/L (geometric mean concentration).
Additional information
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