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EC number: 287-337-9 | CAS number: 85480-57-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From January 01, 1984 to February 14, 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts
- EC Number:
- 270-115-0
- Cas Number:
- 68411-30-3
- IUPAC Name:
- Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Source: F. Winkelmann
Weight at study initiation: 123 g female, 146 g male
Housing: 1-5 animals in Makrolon cages
Diet (e.g. ad libitum): R10 Alleidiaet fuer Ratten, ad libitum
Water (e.g. ad libitum): tap water, ad libitum
Acclimation period: 4-8 d
Temperature (°C): 20 +/- 1
Humidity (%): 60 +/- 5
Air changes (per hr): 15/hr
Photoperiod (hrs dark / hrs light): 12 hrs light/12 hrs dark
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Concentration in vehicle: 12.5-19.9% in water
Maximum dose volume applied: 10 mL/kg - Doses:
- 0, 1250, 14515, 1580 and 1990 mg/kg bw (equivalent to 0, 1075, 1220, 1360 and 1710 mg/kg bw - corrected for 86% purity)
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- Body weight and other signs were measured on Days 7 and 14. Animals were observed for 14 d after dosing. Necropsies were performed at the end of the study.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 080 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- Almost all animals died at doses of 1220 mg/kg bw and above.
- Clinical signs:
- Symptoms beginning about 30 min post application included diarrhea, squatting attitude, breathing difficulties, nose bleeding, ataxia, and lethargy. These symptoms had disappeared in surviving animals by 120 h.
- Body weight:
- No effects on body weight were seen.
- Gross pathology:
- In the animals that died before the end of the study, red mucous was seen in the stomach and intestine. In the surviving animals, hyperemia of the stomach was noted, along with abnormalities of the stomach, liver, spleen, kidneys, and the peritoneum.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Under the study conditions, the acute oral LD50 of the substance was determined to be 1080 mg/kg bw in rats.
- Executive summary:
A study was conducted to determine the acute oral toxicity of the test substance according to OECD Guideline 401. The test substance was administered to male and female rats by oral gavage at doses of 0, 1075, 1220, 1360 or 1710 mg/kg bw (active ingredient). Animals were observed for 14 d after dosing. Body weights were measured on Days 7 and 14. Necropsies were performed at the end of the study. Almost all animals died at doses of 1220 mg/kg bw and above. Symptoms beginning about 30 min post administration included diarrhea, squatting, breathing difficulties, nose bleeding, ataxia, and lethargy. These symptoms disappeared in surviving animals by 120 h. No effects on body weight were seen. In the animals that died before the end of the study, red mucous was seen in the stomach and intestine. In the surviving animals, hyperemia of the stomach was noted, along with abnormalities of the stomach, liver, spleen, kidneys, and the peritoneum. Under the study conditions, the acute oral LD50 of the substance was determined to be 1080 mg/kg bw in rats (Murmann, 1984).
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