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EC number: 200-917-8 | CAS number: 75-94-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04.06.03 to 18.06.03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to a test protocol that is comparable to the appropriate OECD test guideline, and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- starting dose 200 mg/kg bw instead of 300 mg/kg bw.
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Trichloro(vinyl)silane
- EC Number:
- 200-917-8
- EC Name:
- Trichloro(vinyl)silane
- Cas Number:
- 75-94-5
- Molecular formula:
- C2H3Cl3Si
- IUPAC Name:
- trichloro(vinyl)silane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland
- Age at study initiation: 9 weeks
- Weight at study initiation: Body weight variation did not exceed ±20% of mean for the sex.
- Fasting period before study: overnight
- Housing: Macrolon Type IV cages
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ±3
- Humidity (%): 30-70
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: 04.06.03 to 18.06.03 (treatment dates)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: dehydrated olive oil with silica gel (3:1)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: No data
- Amount of vehicle (if gavage): No data
- Justification for choice of vehicle: Based on trial formulations
- Lot/batch no. (if required): No data
- Purity: No data
MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg bw
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: No data - Doses:
- 200 and 2000 (females only) mg/kg bw
- No. of animals per sex per dose:
- Three
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Mortality: twice daily. Body weights: Day 1 (pre-administration), and Days 8 and 15. Clinical signs: periodically on the day of dosing and then daily.
- Necropsy of survivors performed: yes
- Other examinations performed: gross pathological examination - Statistics:
- No statistical analysis.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 200 - <= 2 000 mg/kg bw
- Mortality:
- No animals died when treated with 200 mg/kg bw. All females doses with 2000 mg/kg bw died within two hours of treatment.
- Clinical signs:
- At 200 mg/kg bw hunched posture, flat gait, piloerection, lethargy and alopecia (females) were observed. At 2000 mg/kg bw lethargy, hunched posture, uncoordinated movements, laboured breathing, rales, piloerection, bleeding from the snout, salivation, watery discharge from the eyes, pale appearance, ptosis and clonic spasms. The surviving animals had recovered from the symptoms between days 2 and 3, except for alopecia, which was observed throughout the observation period.
- Body weight:
- No effect on body weight.
- Gross pathology:
- At 2000 mg/kg bw dark red discolouration of the forestomach was observed. There were no findings in animals that survived to the end of the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In a good quality acute oral toxicity study conducted to OECD test guideline 423 (acute toxic class) and GLP, the LD50 for trichloro(vinyl)silane was in the range of 200-2000 mg/kg bw in rats.
- Executive summary:
In a good quality acute oral toxicity study conducted to OECD test guideline 423 (acute toxic class) and GLP, an initial dose of 200 mg/kg bw trichloro(vinyl)silane was administered to three female Wistar rats. In a stepwise procedure additional groups of animals were dosed with 200 mg/kg bw (males) and 2000 mg/kg bw (females). All animals were observed daily and body weights were measured weekly. At the end of a 14 day observation period all surviving animals were sacrificed. Macroscopic examinations were performed on all animals. No deaths occurred at 200 mg/kg bw, and all three females died within two hours after being given a dose of 2000 mg/kg bw. Therefore the oral LD50 was in the range 200 -2000 mg/kg bw. At 200 mg/kg bw hunched posture, flat gait, piloerection, lethargy and alopecia (females) were observed. At 2000 mg/kg bw lethargy, hunched posture, uncoordinated movements, laboured breathing, rales, piloerection, bleeding from the snout, salivation, watery discharge from the eyes, pale appearance, ptosis and clonic spasms. The surviving animals ahd recovered from the symptoms between days 2 and 3, except for alopecia, which was observed throughout the observation period. At 2000 mg/kg bw dark red discolouration of the forestomach was observed. There were no effects on body weight.
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