Registration Dossier
Registration Dossier
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EC number: 201-029-3 | CAS number: 77-47-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- other: expert assessment
- Adequacy of study:
- weight of evidence
- Study period:
- 6 March 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: An assessment was performed based on the Harmonised Classification and data on the in vivo skin corrosion of the substance.
Data source
Reference
- Reference Type:
- other: expert assessment
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- An assessment was performed based on the Harmonised Classification and data on the in vivo skin corrosion of the substance.
- GLP compliance:
- no
Test material
- Reference substance name:
- Hexachlorocyclopentadiene
- EC Number:
- 201-029-3
- EC Name:
- Hexachlorocyclopentadiene
- Cas Number:
- 77-47-4
- Molecular formula:
- C5Cl6
- IUPAC Name:
- hexachlorocyclopentadiene
Constituent 1
Results and discussion
In vivo
Results
- Remarks on result:
- other: An assessment was performed based on the Harmonised Classification and data on the in vivo skin corrosion of the substance.
- Irritant / corrosive response data:
- Hexachlorocyclopentadiene is corrosive to the skin and should be classified as Skin Corr. 1B; H314.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- Hexachlorocyclopentadiene is corrosive to the skin and should be classified as Skin Corr. 1B; H314.
- Executive summary:
A Harmonised Classification as Skin Corr. 1B; H314 is currently attributed to Hexachlorocyclopentadiene for skin irritation and corrosion. This Harmonised Classification was translated from Directive 67/548/EEC and should therefore be considered as a minimum classification unless there is evidence showing that the substance should be classified more severely.
The available data on the skin irritation and corrosion indicate that the substance is corrosive to the skin but does not provide evidence showing that Hexachlorocyclopentadiene should be classified more severely than the current Harmonised Classification. In conclusion, Hexachlorocyclopentadiene is corrosive to the skin and should be classified as Skin Corr. 1B; H314. It is not considered relevant to perform an additional study on the potential of the substance to induce skin corrosion.
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