Registration Dossier
Registration Dossier
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EC number: 298-078-6 | CAS number: 93777-46-9
Endpoint summary
Administrative data
Description of key information
Skin irritation (OECD 439): not irritating
Eye irritation (similar to OECD 492): not irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin Irritation (in vitro)
CAS 93777-46-9
The skin irritation properties of Decyl 2-Ethylhexanoatewere tested in a study according to OECD 439 and EU Method B.46 and in compliance with GLP (Eurlings, 2016). The EPISKIN Small Model™ was exposed to 25 μL of the unchanged test material for 15 ± 0.5 minutes and was incubated for another 42 hours after one washing step. The MTT test revealed a mean tissue viability of 102%. Therefore, Decyl 2-Ethylhexanoate is not regarded as skin irritant.
Eye irritation (in vitro)
CAS 93777-46-9
The eye irritation properties of Decyl 2-Ethylhexanoatewere tested in a study according to OECD 492 and in compliance with GLP (Eurlings, 2015). The EpiOcular™ cornea epithelial model was exposed to 50 μL of the neat/ undiluted test material for 30 ± 2 minutes and was incubated for another 2 hours after rinsing and removal of the test item. The MTT test revealed a mean tissue viability of 88%. Based on the obtained results, Decyl 2-Ethylhexanoate is not eye irritating.
Conclusion on skin and eye irritation properties
The available data on skin irritation with Decyl 2-Ethylhexanoate (CAS 93777-46-9) do not meet the criteria for classification according to Regulation (EC) No 1272/2008, as the classification criteria according to OECD 437 were not met (< 50% of the mean viability of the negative control) and are therefore conclusive but not sufficient for classification.
The available data on eye irritation with Decyl 2-Ethylhexanoate (CAS 93777-46-9) do not meet the criteria for classification according to Regulation (EC) No 1272/2008, as the classification criteria according to OECD 492 were not met (< 50% of the mean viability of the negative control) and are therefore conclusive but not sufficient for classification.
Justification for classification or non-classification
The available data on irritation do not meet the classification criteria according to Regulation (EC) 1272/2008, and are therefore conclusive but not sufficient for classification.
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