Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 236-100-8 | CAS number: 13161-30-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Short term toxicity to aquatic invertebrates:
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, toxicity on Daphnia magna was predicted for 2-Hydroxypyridine 1-oxide (13161-30-3).The EC50 value was estimated to be 180.94 mg/l when 2-Hydroxypyridine 1-oxide was exposed to Daphnia magna for 48hrs.
Toxicity to aquatic algae and cyanobacteria:
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, the toxicity on Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) was predicted for Target substance 2-Hydroxypyridine 1-oxide (13161-30-3) EC50 value was estimated to be 158.0.54 mg/l for Species Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) for 72 hrs duration when exposed to 2-Hydroxypyridine 1-oxide.
Based on this value it can be concluded that the substance 2-Hydroxypyridine 1-oxide is considered as not toxic to aquatic environment as per the criteria mentioned in CLP regulation.
Additional information
Toxicity of the chemical 2-Hydroxypyridine 1-oxide (13161-30-3) on the growth and other activity of aquatic invertebrates and algae was studied by considering and collecting the data from various databases for target chemical and also for some RA (read across) chemicals.
Short term toxicity to aquatic invertebrates:
The toxicity of the chemical 2-Hydroxypyridine 1-oxide (13161-30-3) on the growth of aquatic invertebrates was studied by considering and collecting the data from various databases for target chemical. Some RA (read across) chemicals were also studied. The result are summarised as below:
In the first weight of evidence study for 2-Hydroxypyridine 1-oxide (13161-30-3) based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, toxicity on Daphnia magna was predicted for 2-Hydroxypyridine 1-oxide (13161-30-3).The EC50 value was estimated to be 180.94 mg/l when 2-Hydroxypyridine 1-oxide was exposed to Daphnia magna for 48hrs.
In the second weight of evidence study for target chemical 2-Hydroxypyridine 1-oxide (13161-30-3) ECOSAR, 2017. Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted. On the basis of this program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be 22147 mg/l 2- Hydroxy -pyridine 1-oxide in 48 hrs. Based on this value it can be concluded that the substance is considered to be not toxic to aquatic environment and cannot be classified as toxic as per the criteria mentioned in CLP regulation.
Similarly in the third weight of evidence study for RA chemical (108-80-5) J-check, Short-term toxicity study of Isocyanuric acid on the mobility of aquatic invertebrates for 48 hrs. Test was performed in static conditions. Based on the immobilization of daphnia due to Isocyanuric acid, the EC50 was 1000mg/l. Based on the EC50 value, the chemical Isocyanuric acid was not toxic and can be consider to be classified as nontoxic as per the CLP classification criteria.
Similarly in the fourth weight of evidence study for another RA chemical 123-33-1 (1,2-Dihydro-3,6-pyridazinedione) from HSDB and ECOTOX, 2017, Short term toxicity of Maleic hydrazide (1,2-Dihydro-3,6-pyridazinedione) on the growth of daphnia magna was studied for 48 hrs. Test was performed by static system on 1 ins age of fish. Based on the intoxication of daphnia magna by the exposure of Maleic hydrazide (1,2-Dihydro-3,6-pyridazinedione) the EC50 was 107.5 mg/l. Based on the EC50 value Maleic hydrazide (1,2-Dihydro-3,6-pyridazinedione) was not toxic and cannot be consider as classified as toxic to aquatic environment as per the CLP classification criteria.
Based on the data from various sources, it can be concluded that the substance 2-Hydroxypyridine 1-oxide is likely to be not toxic at environmentally relevant concentrations and can be considered as 'not classified' as per the criteria mentioned in CLP regulation.
Toxicity to aquatic algae and cyanobacteria:
The toxicity of the chemical 2-Hydroxypyridine 1-oxide (13161-30-3) on the growth of aquatic algae was studied by considering and collecting the data from various databases for target chemical. Some RA (read across) chemicals was also studied. The results are summarised as below:
In the first weight of evidence study for 2-Hydroxypyridine 1-oxide (13161-30-3) based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, the toxicity on Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) was predicted for Target substance 2-Hydroxypyridine 1-oxide (13161-30-3). EC50 value was estimated to be 158.0.54 mg/l for Species Pseudokirchneriella subcapitata for 72 hrs duration when exposed to 2-Hydroxypyridine 1-oxide. Based on this value it can be concluded that the substance 2-Hydroxypyridine 1-oxide is considered as not toxic to aquatic environment as per the criteria mentioned in CLP regulation.
In the second weight of evidence study for target chemical 2-Hydroxypyridine 1-oxide (13161-30-3) ECOSAR, 2017, Based on the prediction done using the EPI Suite ECOSAR version 1.11, the short term toxicity on green algae was predicted for test substance pyridin-2-ol 1-oxide (13161 -30 -3). On the basis of effects observed in a static freshwater system, the effect concentration EC50 value for the substance is estimated to be 5117 mg/l for green algae for 98 hrs duration. Based on this value, it can be concluded that the test chemical pyridin-2-ol 1-oxide can be considered as non-toxic to green algae at environmentally relevant concentrations and can be considered not-classified as toxic as per the CLP classification criteria.
Similarly in the third weight of evidence study for RA chemical (108-80-5) J-check and HSDB, 2017, Short term toxicity study of Isocyanuric acid (IUPAC name 1,3,5-Triazin-2,4,6-triol )on the growth of freshwater green algae was carried out for 72 hrs. The effective concentration (EC50) value of aquatic green algae in a 72 hr study on the basis of growth rate effect and AUG was 950 mg/l and 620 mg/l. But the NOEC on the basis of growth rate AUG and was 250 mg/l and 22 mg/l. Based on the growth rate and AUG of green algae by considering EC50, Isocyanuric acid (IUPAC name 1,3,5-Triazin-2,4,6-triol ) was nontoxic and cannot be classified as toxic to aquatic algae as per the CLP classification criteria.
Similarly in the fourth weight of evidence study for RA chemical (108-80-5) from IUCLID dataset Short term toxicity study of Isocyanuric acid (IUPAC name 1,3,5-Triazin-2,4,6-triol )on the growth of freshwater green algae Selenastrum capricornutums was carried out for 96 hrs. The effective concentration (EC50) value of aquatic green algae in a 96 hr. study on the basis of biomass was 712 mg/l, but the NOEC and LOEC on the basis of biomass was ≤ 100 mg/l and 320 mg/l. Based on the inhibition of biomass of green algae by considering EC50, cyanuric acid (IUPAC name 1,3,5-Triazin-2,4,6-triol ) was nontoxic and cannot be classified as toxic to aquatic algae as per the CLP classification criteria.
Based on this value it can be concluded that the substance 2-Hydroxypyridine 1-oxide is likely to be non toxic to aquatic algae at environmentally relevant concentrations and can be considered as 'not classified' as per the criteria mentioned in CLP regulation.
Based on the data from various sources for invertebrates and algae, it can be concluded that the substance 2-Hydroxypyridine 1-oxide is considered to be not toxic to aquatic environment and can be classified as non-toxic as per the criteria mentioned in CLP regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.