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EC number: 250-078-7 | CAS number: 30168-23-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- According to FDA methos at the time.
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-(tricyclo[5.2.1.02,6]dec-8-ylidene)butyraldehyde
- EC Number:
- 250-078-7
- EC Name:
- 4-(tricyclo[5.2.1.02,6]dec-8-ylidene)butyraldehyde
- Cas Number:
- 30168-23-1
- Molecular formula:
- C14H20O
- IUPAC Name:
- 4-[(8Z)-tricyclo[5.2.1.0^{2,6}]decan-8-ylidene]butanal
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Dupical: U 05481
A clear yellowish liquid.
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Acclimatisation: 3 days.
Individually housed.
Temperature: 23 +/0 1'C.
Relative humidity: 50 +10%.
12 hour light and dark cycle.
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 100%
- Duration of treatment / exposure:
- No eye washing conducted.
- Observation period (in vivo):
- 7 days observation (24, 48 and 72 hours and 7 days).
- Number of animals or in vitro replicates:
- Test 1: 6 animals.
Test 2: 6 animals.
Test 3: 6 animals.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 3
- Reversibility:
- other: Study did not go to 21 days but expected to be reversible
- Remarks on result:
- other: Test 1
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- other: Study did not go to 21 days but expected to be reversible
- Remarks on result:
- other: Test 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.9
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: Test 3
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: Test 3
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: Study did not go to 21 days but expected to be reversible
- Remarks on result:
- other: Test 2
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.055
- Max. score:
- 2
- Reversibility:
- other: Study did not go to 21 days but expected to be reversible
- Remarks on result:
- other: Test 1
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: Study did not go to 21 days but expected to be reversible
- Remarks on result:
- other: Test 1
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: Study did not go to 21 days but expected to be reversible
- Remarks on result:
- other: Test 2
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: Test 3
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.89
- Max. score:
- 4
- Reversibility:
- other: Study did not go to 21 days but expected to be reversible
- Remarks on result:
- other: Test 1
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.83
- Max. score:
- 4
- Reversibility:
- other: Study did not go to 21 days but expected to be reversible
- Remarks on result:
- other: Test 2
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.61
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: Test 3
- Irritant / corrosive response data:
- Since the results obtained from the first and the second test were still inconclusive, a third test was performed. In the third experiment the test-material caused moderate redness and slight swelling of the conjunctivae in one animal and slight redness and/or swelling of the conjunctivae in all other animals. After seven days slight conjunctivitis wasstill noticeable in two animals. Overall it may be said that Dupical is not an eye irritant.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- On the basis of the present results it is concluded that according to FDA standards Dupical is not considered to be an eye irritant.
Although a low level of eye irritation was observed in the 3 tests carried out, the severity does not fulfill the current GHS or EU classification criteria. - Executive summary:
The product Dupical was examined for eye irritation and phototoxicity. New Zealand White albino rabbits were used as the experimental animals. According to FDA standards, Dupical is not considered to be an eye irritant. A 10% dilution of Dupical in absolute ethanol was not found to be phototoxic.
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