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EC number: 255-707-9 | CAS number: 42204-14-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7 April 1986 – 22 April 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted according to OECD guideline No. 405 and to GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Rhodium(3+) acetate
- EC Number:
- 247-460-0
- EC Name:
- Rhodium(3+) acetate
- Cas Number:
- 42204-14-8
- Molecular formula:
- C6H9O6Rh
- IUPAC Name:
- Rhodium(3+);triacetate
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): rhodium (III) acetat “braun”
- Substance type: brown crystal
- Physical state: solid
- Composition of test material, percentage of components: 39.54% Rh
- Lot/batch No.: 6091
- Stability under test conditions: stable throughout the test period
- Storage condition of test material: at room temperature
- Other: soluble in water
1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: White Russian (albino)
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Asta-Werke AG, D-4800 Bielefeld 14
- Age at study initiation: 4-8 months
- Weight at study initiation: 2.0-2.3 kg
- Housing: individually
- Diet: ad libitum standard diet, ssniff K “special diet for rabbits” supplied by ssniff Spezialfutter GmbH, D-4770 Soest
- Water: ad libitum
- Acclimation period: 1 day before application of test material
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2
- Humidity (%): 55 ± 15
- Photoperiod (hrs dark / hrs light): 6 am-6 pm fluorescent tube lighting, 6 pm-6 am “natural light-dark-rhythm”
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 g - Duration of treatment / exposure:
- Eye not rinsed, therefore 15 days
- Observation period (in vivo):
- 1, 24, 48 and 72 hrs post application and thereafter once daily to day 15 post-application
- Number of animals or in vitro replicates:
- 1 male and 2 females
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): not done
SCORING SYSTEM: Signs of irritation on the cornea, iris and conjunctiva were assessed quantitatively and qualitatively using the Draize scale and the mean values of the individual grades at examination times 1, 24, 48 and 72 hrs expressed by an irritation index (see below):
Irritation index Evaluation
0 – 10 non-irritant
11 – 25 slightly irritant
26 – 56 moderately irritant
57-110 severely irritant
TOOL USED TO ASSESS SCORE: Cliptrix pencil light (No. 645) supplied by Varta, Hanover.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1, 24, 48 and 72 hrs
- Score:
- ca. 42
- Max. score:
- 110
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- other: Hair loss around the eyes was still evident at 15 days post-application.
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1, 24, 48 and 72 hrs
- Score:
- ca. 27.5
- Max. score:
- 80
- Reversibility:
- fully reversible within: 9 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1, 24, 48 and 72 hrs
- Score:
- ca. 3.8
- Max. score:
- 10
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1, 24, 48 and 72 hrs
- Score:
- ca. 10.5
- Max. score:
- 20
- Reversibility:
- fully reversible within: 14 days
- Other effects:
- During the first week of observation there was discharge which moistened the lids and hairs just adjacent to the lids and considerable areas around the eyes. Also loss of hair around the eyes occurred. There were no systemic toxic effects and the general condition of the animals was unaffected after conjunctival instillation of the test material.
Any other information on results incl. tables
Table 1: Individual irritation scores for each timepoint.
Eye reaction | Time after exposure/hr | Draize score | ||
Animal 1 | Animal 2 | Animal 3 | ||
Corneal opacity | 1 | 0 | 2 | 1 |
24 | 1 | 2 | 1 | |
48 | 1 | 2 | 2 | |
72 | 1 | 2 | 2 | |
Corneal area | 1 | 0 | 3 | 4 |
24 | 4 | 4 | 4 | |
48 | 4 | 4 | 4 | |
72 | 4 | 4 | 4 | |
Iris | 1 | 0 | 1 | 0 |
24 | 1 | 1 | 1 | |
48 | 1 | 1 | 1 | |
72 | 0 | 1 | 1 | |
Conjunctival redness | 1 | 1 | 0 | 1 |
24 | 2 | 2 | 3 | |
48 | 3 | 3 | 3 | |
72 | 3 | 3 | 3 | |
Chemosis | 1 | 0 | 2 | 1 |
24 | 1 | 2 | 1 | |
48 | 1 | 2 | 2 | |
72 | 1 | 2 | 2 | |
Discharge | 1 | 0 | 1 | 1 |
24 | 2 | 3 | 2 | |
48 | 1 | 2 | 2 | |
72 | 1 | 2 | 2 |
Applicant's summary and conclusion
- Interpretation of results:
- Category II
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In a guideline study, to GLP, rhodium (III) acetate “brown” (0.1 g) produced a primary irritation index of 42 (out of 110) following instillation into the conjunctival sac of three rabbits and, therefore, was considered as moderately irritant in this test system.
- Executive summary:
In an OECD Test Guideline 405 study, conducted according to GLP, rhodium (III) acetate “brown” (0.1 g) was instilled into the conjunctival sac of one eye of one male and 2 female White Russian rabbits and both lids were briefly closed by gentle finger pressure. The other eye remained untreated and acted as the control. The treated eye was assessed, without rinsing, both quantitatively and qualitatively, for signs of irritation on the cornea, iris and conjunctiva using the Draize scale after 1, 24, 48 and 72 hr and once daily, thereafter, for up to 15 days post-application.
The sum of the scores at observation times 1, 24, 48 and 72 hrs was combined to give an irritation index of 42 (out of 110) and the test material was, therefore, considered as moderately irritant in this test system. All three animals displayed conjunctival redness scores (averaged over 24, 48 and 72-hr time points) of at least 2, while in two animals corneal opacity scores were above 1 and chemosis scores were at least 2. The observed irritation was fully reversible within the 15-day observation period. As well as the irritant effects, a discharge with moistening of the lids and hairs adjacent to the lids or considerable areas around the eye arose during the first week of observation, while beyond this time there was loss of hair around the eye. No corrosive effects or systemic toxicity were observed, and the general condition of the animals was unaffected by treatment.
Based on the results of this study, the test material would be classified as irritating to the eyes (Category 2) according to EU CLP criteria (EC 1272/2008).
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