Registration Dossier
Registration Dossier
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EC number: 207-079-2 | CAS number: 431-89-0
Endpoint summary
Administrative data
Description of key information
The NOAEL for repeated dose toxicity is higher than 731690 mg/m3 (105000 ppm) in rats exposed for a period of 90 days.
Key value for chemical safety assessment
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 731 690 mg/m³
Additional information
In accordance with section 2 of REACH Annex XI, studies via the oral and dermal route do not need to be conducted as the substance is a gas.
Repeated administration of 1,1,1,2,3,3,3-heptafluoropropane (HFC 227ea) to rats by inhalation over 90 days (WIL Research Laboratories, 1993a) did not induce treatment-related effects at any dose tested (139370, 348420 and 731690 mg/m3 (20000, 50000 and 105000 ppm). All treated animals survived until termination. The NOAEC for systemic toxicity was established to be > 731690 mg/m3 (105000 ppm), 6 hr/day.
The NOAEC of 731690 mg/m3 observed in the subchronic inhalation toxicity study with rats will be used for DNEL derivation for repeated dose toxicity.
Justification for classification or non-classification
Based on the absence of any adverse effects in a subacute and semichronic toxicity study with rats, classification for repeated dose toxicity is not warranted according to EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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