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EC number: 240-299-7 | CAS number: 16143-80-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from HPVIS database.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Acute dermal toxicity for CAS 101-02-0
- Author:
- U.S Environmental Protection agency
- Year:
- 2 018
- Bibliographic source:
- High Production Volume Information System (HPVIS)
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- The method employed in the testing, evaluation, and the scoring of the results was similar to the methods described in Section 1500.40 of the U.S. Federal Hazardous Substances Act Regulations, 16 CFF, pg. 123. [Comparable to OECD Test Guideline 402]
- Principles of method if other than guideline:
- Acute dermal toxicity of Phosphorous acid, triphenyl ester (CAS no.: 101-02-0) in rabbit
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Triphenyl phosphite
- EC Number:
- 202-908-4
- EC Name:
- Triphenyl phosphite
- Cas Number:
- 101-02-0
- Molecular formula:
- C18H15O3P
- IUPAC Name:
- Triphenyl phosphite
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Phosphorous acid, triphenyl ester
- Molecular formula (if other than submission substance): C18-H15-O3-P
- Molecular weight (if other than submission substance): 310.2875
- Substance type: Organic
- Physical state: liquid
- Purity: > 97%
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Weight at study initiation: between 2.0 and 3.0 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The sample was dosed as supplied (described as a colorless to straw-colored liquid).
- Duration of exposure:
- 24 hours
- Doses:
- 2 and 5 g/kg
- No. of animals per sex per dose:
- 3/sex
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 21-day
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 2 000 - <= 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- At a dose of 5 g/kg, all three males and females died. At 2 g/kg, no animals died.
- Clinical signs:
- other: At a dose of 5 g/kg: After 5-6 hours, the animals appeared cold, and lethargic. They became semi-comatose after 8 hours and deaths occurred over approximately 2-3 days after dosing. At dose 2mg/kg: there were no remarkable findings, except for substantial
- Gross pathology:
- At dose 2mg/kg: Gross pathological examination revealed no remarkable findings.
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- Acute dermal LD50 value of the substance Phosphorous acid, triphenyl ester was determined to be in between the range of > 2000 - < 5000 mg/kg for New Zealand white rabbits.
- Executive summary:
Acute dermal toxicity of the substance Phosphorous acid, triphenyl ester (CAS 101-02-0) was determined in New Zealand white rabbits as per the methods described in Section 1500.40 of the U.S. Federal Hazardous Substances Act Regulations, 16 CFF, pg. 123. [Comparable to OECD Test Guideline 402]. The sample was applied as supplied to the back of each animal at dose of 5.0 g/kg body weight. These treated areas were covered with large gauze patches and an impervious material was wrapped around the trunk of each animal. The dressings were removed after 24 hours and any excess material was removed. The animals were observed for a 21-day period for signs of toxicity and mortality. At a dose of 5 g/kg, all three males and females died. After 5-6 hours, the animals appeared cold, and lethargic. They became semi-comatose after 8 hours and deaths occurred over approximately 2-3 days after dosing. At 2 g/kg, no animals died and there were no remarkable findings, except for substantial skin irritation lasting over several days. Gross pathological examination revealed no remarkable findings. Thus, acute dermal LD50 value of the substance Phosphorous acid, triphenyl ester was determined to be in between the range of > 2000 - < 5000 mg/kg for New Zealand white rabbits.
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