Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 218-817-8 | CAS number: 2243-62-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
Effect level for oral exposure: 2 mg/kg bw/day.
Short description of key information:
In a study according OECD gideline 414, 25 female Wistar-rats received 1,5 -naphthylenediamine by gavage (dose: 0; 2; 10; 50 mg/kg bw.) daily from day 6 to day 15 of gestation.
From 10 mg/kg bw./day the food consumption and weight gain were influenced.
In the 50 mg/kg dose group sporadic heightened urine excretion was observed and additionally in one animal an increased water consumption detected.
No meaningfull pathological-anatomical findings and no mortalities were observed.
From 10 mg/kg bw/day a marginal diminuated weight of fetuses was identified.
The NOAEL for maternal toxicity and developmental toxicity was 2 mg/kg bw/day (Bartmann 1993).
There are no further valid data available to characterize the toxicity to reproduction of Alphamin.
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
