Registration Dossier
Registration Dossier
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EC number: 208-401-4 | CAS number: 526-95-4
Dissociation constant
Administrative data
Link to relevant study record(s)
Description of key information
A TGD-approved handbook states that the notional solid structure has a dissociation constant of 3.6 at 25°C, suggesting that at the ambient pH of 3.6, half the gluconic acid molecules will exist in the form of the uncharged acid, and half as the anion. At pH < 3.6, the undissociated form will predominate, and pH > 3.6 the anion will predominate. Therefore, gluconic acid will exist predominantly in the form of the dissociated anion throughout the range of pH 4 to 9.
Key value for chemical safety assessment
Additional information
Information regarding dissociation constant of 50% aqueous solution of gluconic acid was based on the notional solid structure and was sourced from two separate handbooks. Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (14th Ed.) and Ullmann's Encylopedia of Industrial Chemistry (7th Ed.) report that gluconic acid (free acid) has a dissociation constant of 3.6 and 3.7 at 25°C, respectively. Although the information from both sources is comparable, the data obtained from Ullmann’s handbook is not TGD-approved, and as such is of Klimish-4 reliability and is not considered valid.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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