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EC number: 280-349-5 | CAS number: 83261-15-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983-08-23 to 1983-09-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable with guideline study (non-GLP).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
- Principles of method if other than guideline:
- BASF-Test, principally according to OECD guideline 403.
- GLP compliance:
- no
- Test type:
- fixed concentration procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Isobutyl (S)-2-chloropropionate
- EC Number:
- 280-349-5
- EC Name:
- Isobutyl (S)-2-chloropropionate
- Cas Number:
- 83261-15-8
- Molecular formula:
- C7H13ClO2
- IUPAC Name:
- isobutyl (S)-2-chloropropanoate
- Details on test material:
- - Name of test material (as cited in study report): L-chloropropionic acid isobutyl ester
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Lot/batch No.: P 4/83
No further data.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
male and female SPF Wistar /Chbb:Thom rats
- Source: Dr . K . Thomae GmbH, 7950 Biberach, Germany
- Age at study initiation: 8 weeks
- Weight at study initiation: mean weight: 240 g (males), 168 g (females)
- Fasting period before study: no data
- Housing: 3 per cage, steel cages (Becker, type D III)
- Diet (ad libitum): KLIBA Labordiät Ratte/Maus A 343 10 mm Pellet, Klingentalmühle AG, CH-4303 Kaiseraugst (Switzerland)
- Water: tap water, ca. 250 ml per cage/day
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
A 5-cm layer of the test material was filled into a fritted glass disc (diameter 30 cm) and weighed. An air stream (200 l/h) was bubbled through this substance layer at a temperature of 19-21°C. The so generated substance-air mixture was conducted through 6 glass tubes. In these tubes, 6 rats (3 males, 3 females) had been placed. Exposure temperature was 19-25 °C. Exhausted air/mixture was discarded.
The fritted glass containing the test substance was replaced after 30 minutes. The new substance was used for the remainder of the exposure period. The loss of test material was determined by re-weighing the residual test material in the fritted glasses.
Total exposure time was 7 hours. The aim of the study was to determine the time of exposure which was survived by all animals after a 14-day observation in two experiment. - Analytical verification of test atmosphere concentrations:
- no
- Remarks:
- calculation of nominal concentration
- Duration of exposure:
- 7 h
- Concentrations:
- 8.1 mg/l (nominal); saturated atmosphere
- No. of animals per sex per dose:
- 3 males, 3 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: on working days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology - Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: IHT
- Effect level:
- 8.1 mg/L air (nominal)
- Exp. duration:
- 7 h
- Remarks on result:
- other: no mortality after exposure for 7 h to a saturated vapour atmosphere.
- Mortality:
- No deaths occurred.
- Clinical signs:
- other: During exposure, eyelid closure, serous secretion of eyes and nose (hemotest positive), salivation, and intermittent respiration was noted. After exposure, intermittent respiration and apathy was observed. The animals were normal after one day.
- Body weight:
- no data
- Gross pathology:
- No pathological findings were observed.
Any other information on results incl. tables
The mean concentration of the test substance was estimated to be 8.1 mg/l (nominal).
Applicant's summary and conclusion
- Executive summary:
No mortality was observed when 6 rats were exposed for 7 hours to an atmosphere that had been saturated at 20° with the volatile parts of the compound. The mean concentration of the test substance was 8.1 mg/l (nominal).
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