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EC number: 279-576-2 | CAS number: 80858-47-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 - 24 March 1982
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The present in vivo study can be used because it was performed before the current REACH requirements on in vitro testing (October, 2016)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- (1981)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- [2-(cyclohexyloxy)ethyl]benzene
- EC Number:
- 279-576-2
- EC Name:
- [2-(cyclohexyloxy)ethyl]benzene
- Cas Number:
- 80858-47-5
- Molecular formula:
- C14H20O
- IUPAC Name:
- [2-(cyclohexyloxy)ethyl]benzene
- Test material form:
- liquid
1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- albino strain
- Details on test animals or tissues and environmental conditions:
- - Source: Perfection Breeders, Inc., Douglassville, Pennsylvania
- Age at study initiation: No information provided
- Weight at study initiation: Body weights were in range of 2-3 kg
- Housing: Individually
- Diet: Wayne Rabbit Ration, ad libitum, checked daily and added or replaced as needed, checked for contaminants.
- Water: Fresh tap water, available ad libitum, checked for contaminants.
- Acclimation period: Five days
ENVIRONMENTAL CONDITIONS: The light cycle was: 12 hours light, 12 hours dark. The temperature was attempted to be maintained at the level of 20 ± 3°C and the humidity in the range of 30-70%. The waste material was removed daily. Cages and feeders were sanitized every two weeks.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: One eye of each animal remained untreated and served as the reference control.
- Amount / concentration applied:
- Amount applied (volume or weight with unit): 0.1 mL
- Duration of treatment / exposure:
- Single instillation on Day 1
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 3 males and 3 females
- Details on study design:
- STUDY DESIGN
The test material was applied at 100% in 6 animals (3 males and 3 females).
TREATMENT
In accordance with OECD 405 (1981). The test substance is placed in the conjunctival sac of one eye of each animal after gently pulling the lower lid away from the eyeball. The lids are then gently held together for about one second. The other eye serves at control.
REMOVAL OF TEST SUBSTANCE
-Washing: No
OBSERVATIONS
- Irritation:
The eyes of each animal were examined at 1, 24, 48 and 72 hours and 7 days after instillation of the test substance.
The irritation scores and a description of all other (local) effects were recorded. The irritation was assessed according to OECD 405 (1981).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: #1, 2, 3, 4, 5 and 6 (mean)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: #1, 2, 3, 4, 5 and 6 (mean)
- Time point:
- 7 d
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal: #1, 2, 3, 4, 5 and 6 (mean)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal: #1, 3, 4, 5 and 6 (mean)
- Remarks:
- (mean)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #2
- Remarks:
- (mean)
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- chemosis score
- Basis:
- animal: #1, 2, 3, 4, 5 and 6 (mean)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal: #1, 2, 3, 4, 5 and 6 (mean)
- Time point:
- 7 d
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal: #1, 2, 3, 4, 5 and 6 (mean)
- Time point:
- 7 d
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal: #1, 2, 3, 4, 5 and 6 (mean)
- Time point:
- 7 d
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: #1, 2, 3, 4, 5 and 6 (mean)
- Time point:
- other: 1 hr
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal: #1, 2, 3, 4, 5 and 6 (mean)
- Time point:
- other: 1 hr
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal: #1, 2, 3, 4, 5 and 6 (mean)
- Time point:
- other: 1 hr
- Score:
- 0.83
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 hr
- Irritation parameter:
- chemosis score
- Basis:
- animal: #1, 2, 3, 4, 5 and 6 (mean)
- Time point:
- other: 1 hr
- Score:
- 0.17
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24 hr
Any other information on results incl. tables
Rabbit no. |
Observations |
1 hr |
24 hr |
48 hr |
72 hr |
7 days |
1301 |
Cornea |
0,0=0 |
0,0=0 |
0,0=0 |
0,0=0 |
0,0=0 |
Iris |
0=0 |
0=0 |
0=0 |
0=0 |
0=0 |
|
Conjunctiva |
1,0,0=2 |
0,0,0=0 |
0,0,0=0 |
0,0,0=0 |
0,0,0=0 |
|
1302 |
Cornea |
0,0=0 |
0,0=0 |
0,0=0 |
0,0=0 |
0,0=0 |
Iris |
0=0 |
0=0 |
0=0 |
0=0 |
0=0 |
|
Conjunctiva |
1,0,0=2 |
1,0,0=2 |
0,0,0=0 |
0,0,0=0 |
0,0,0=0 |
|
1303 |
Cornea |
0,0=0 |
0,0=0 |
0,0=0 |
0,0=0 |
0,0=0 |
Iris |
0=0 |
0=0 |
0=0 |
0=0 |
0=0 |
|
Conjunctiva |
0,0,0=0 |
0,0,0=0 |
0,0,0=0 |
0,0,0=0 |
0,0,0=0 |
|
1304 |
Cornea |
0,0=0 |
0,0=0 |
0,0=0 |
0,0=0 |
0,0=0 |
Iris |
0=0 |
0=0 |
0=0 |
0=0 |
0=0 |
|
Conjunctiva |
1,0,0=2 |
0,0,0=0 |
0,0,0=0 |
0,0,0=0 |
0,0,0=0 |
|
1305 |
Cornea |
0,0=0 |
0,0=0 |
0,0=0 |
0,0=0 |
0,0=0 |
Iris |
0=0 |
0=0 |
0=0 |
0=0 |
0=0 |
|
Conjunctiva |
1,0,0=2 |
0,0,0=0 |
0,0,0=0 |
0,0,0=0 |
0,0,0=0 |
|
1306 |
Cornea |
0,0=0 |
0,0=0 |
0,0=0 |
0,0=0 |
0,0=0 |
Iris |
0=0 |
0=0 |
0=0 |
0=0 |
0=0 |
|
Conjunctiva |
1,1,0=4 |
0,0,0=0 |
0,0,0=0 |
0,0,0=0 |
0,0,0=0 |
Applicant's summary and conclusion
- Interpretation of results:
- other: Not an eye irritant
- Remarks:
- According to EU CLP 1272/2008 and its amendments.
- Conclusions:
- In an eye irritation study with rabbits, performed according to OECD 405 (1981), no irritation was observed. Based on the results of this study, the substance is not considered an eye irritant.
- Executive summary:
The substance was tested in an eye irritation test in rabbits according to OECD 405 (1981). Six New Zealand albino rabbits were used (3 males and 3 females). The volume applied was 0.1 ml. Ocular effects included only a slight redness of conjunctiva in 5 out of 6 animals (score 1) at 1 hr, which were fully reversible within 24 hours in 4 animals and within 48 hours in 1 animal. A slight chemosis was observed in 1 animal (score 1) that was fully resolved within 24 hours. No other effects were seen, resulting in absence of eye irritation.
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