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EC number: 814-233-8 | CAS number: 444649-70-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From August 26, 2015 to September 10, 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- not specified
- Type of method:
- flask method
- Specific details on test material used for the study:
- Batch no.: lot # JBGJ0045R
Purity: 100% (UVCB) - Key result
- Water solubility:
- 142 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- ca. 6
- Remarks on result:
- other: nominal loading of aqeous phase: 700 – 7000 mg/L
- Details on results:
- The average of the measurements of the days 1, 2 and 3 each were included in the calculation since the differences between the measured concentrations were below 15%. Dependency of the solubility from the nominal load was not noticed. Based on the results obtained, the water solubility of the test substance was 142 ± 16 mg/L at 20°C.
- Conclusions:
- Under the study conditions, the water solubility of the test substance was determined to be 142 ± 16 mg/L at 20°C (flask method).
- Executive summary:
A study was conducted to determine the water solubility of the test substance, according to OECD guideline 105 and EU Method A.6. Since it was known from pre-test during validation, that water solubility was between 10 mg/L and 1 g/L, the preliminary study which was proposed in the EU-Guideline was not performed. Instead, a flask with nominal load 7 g/L was shaken for 2 days to test the filterability of the mixture. The nominal load of 7 g/L was chosen, because for the main test a maximum concentration of 7 g/L was planned. The mixture resulted in a clear solution after filtration and showed a concentration of 119 mg/L. Therefore, the flask method was used. The value which was detected in the preliminary study was used to calculate the amount of test substance which is necessary to saturate 1000 mL as at least 595 mg (in the guideline, fivefold saturation is proposed). In order to check if the solubility was depending on the nominal load, seven vessels with nominal loads between 700 – 7000 mg/L were used. 35.0– 800.3 mg test substance were weighed into each vessel, 50 - 200 mL water were added, and the sealed flasks were put on the orbital shaker for 24, 48 and 72h (20.0 ± 0.5°C). Then, flasks were taken from the shaker, samples were taken, then filtered and measured after sample preparation via HPLC. The average of the measurements of the Days 1, 2 and 3 each were included in the calculation since the differences between the measured concentrations were below 15%.Dependency of the solubility from the nominal load was not noticed. Under the study conditions, the water solubility of the test substance was determined to be 142 ± 16 mg/L at 20°C (Brinkmann, 2015).
Reference
Description of key information
The water solubility was determined according to OECD guideline 105 and EU Method A.6 (flask method) (Brinkmann, 2015)
Key value for chemical safety assessment
- Water solubility:
- 142 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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