Tetraamminepalladium(2+) dichloride

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

4 October 2010 to 13 December 2010

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP complaint, guideline study, available as unpublished report acceptable without restrictions

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)

Version / remarks:

Screening Test

Principles of method if other than guideline:

The method used is based on a procedure designed to comply with that given in 'Particle size distribution, fibre length and diameter distribution', June 1996 European Commission technical guidance document, which satifies the requirements of OECD Guideline 110

GLP compliance:

yes (incl. QA statement)

Type of method:

sieving

No.:

#1

Size:

< 100 µm

Distribution:

16.2 %

The results of the sieving procedure are shown below:

Measurement	Result
Mass of test item transferred to sieve	10.13g
Mass of test item passed through sieve	1.64g
Proportion of test item <100µm	16.2%

Conclusions:

In an OECD 110 Granulometry (Screening Test) the proportion of Tetraamminepalladium (2+) dichloride <100 μm was 16.2 %

Executive summary:

This is a GLP compliant, guideline study considered suitable for use as the key study for this endpoint. The proportion of Tetraamminepalladium (2+) dichloride < 100 μm is 16.2 %

Description of key information

The proportion of tetraamminepalladium (2+) dichloride <100 μm was 16.2 %.

Additional information

Atwal and Tremain (2011) is a GLP compliant, guideline study considered suitable for use as the key study for this endpoint. The proportion of tetraamminepalladium (2+) dichloride < 100 μm is 16.2 %.

The dustiness of tetraamminepalladium(2+) dichloride was tested in a modified Heubach procedure according to the guideline DIN 55992-1:2006 (Selck and Parr 2011). The study is non-GLP, but follows a standard guideline and is considered to be reliable. The total dustiness of tetraamminepalladium(2+) dichloride was determined to be 99.93 mg/g. The inhalable fraction was 61.67 mg/g, the thoracic fraction was 11.96 mg/g and the respirable fraction was 1.40 mg/g. The Mass Median Aerodynamic Diameter (MMAD) was 25.72 μm with Geometric Standard Deviation of 1.91 μm.