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EC number: 232-178-2 | CAS number: 7789-60-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity:
LD50 was considered to be < 50 mg/kg bw when rat were treated with phosphorus (3+) tribromide orally.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity study of phosphorus (3+) tribromide in rats
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material : Phosphorus tribromide (phosphorus (3+) tribromide)
- Molecular formula: Br3P
- Molecular weight : 270.686 g/mole
- Smiles notation :P(Br)(Br)Br
- InChl :1S/Br3P/c14(2)3
- Substance type: Inorganic
- Physical state: Solid - Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- not specified
- Doses:
- 50,400 and 3200 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs and body weight were examined. - Statistics:
- not specified
- Preliminary study:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- < 50 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: More than 50 % mortality was observed
- Mortality:
- More than 50 % mortality was observed in treated rats at 50 mg/kg bw within 2 min-1 day after dosing
- Clinical signs:
- other: Weakness, prostration (wet around mouth, difficult breathing) were observed.
- Gross pathology:
- not specified
- Other findings:
- not specified
- Interpretation of results:
- Category 2 based on GHS criteria
- Conclusions:
- LD50 was considered to be < 50 mg/kg bw when rat were treated with phosphorus (3+) tribromide orally.
- Executive summary:
In a acute oral toxicity study, rat were treated with phosphorus (3+) tribromide in the concentration of 50,400 and 3200 mg/kg bw orally. 50 % mortality was observed in treated rats at 50 mg/kg bw within 2 min-1 day after dosing. Weakness, prostration (wet around mouth, difficult breathing) were observed. Therefore,LD50 was considered to be< 50 mg/kg bw when rat were treated with phosphorus (3+) tribromide orally.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 50 mg/kg bw
- Quality of whole database:
- Data is klimiach 4 and from secondary source
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute oral toxicity:
In different studies, phosphorus (3+) tribromide has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments in rodents, i.e. most commonly in rats for phosphorus (3+) tribromide along with the study available on structurally similar read across substance phosphorus (3+) trichloride (CAS no 7719-12-2).
In a experimental study conducted by Eastman Kodak Co (OTS0555394, Eastman Kodak Company, 1992), rat were treated with phosphorus (3+) tribromide in the concentration of 50,400 and 3200 mg/kg bw orally. 50 % mortality was observed in treated rats at 50 mg/kg bw within 2 min-1 day after dosing. Weakness, prostration (wet around mouth, difficult breathing) were observed. Therefore, LD50 was considered to be < 50 mg/kg bw when rat were treated with phosphorus (3+) tribromide orally.
In another experimental study given by U.S. National Library of Medicine (ChemIDplusA TOXNET DATABASE, 2017) and German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety and the Environmental Ministries of all 16 Federal States of Germany (GSBL – Joint Substance Data Pool of the German Federal Government and the German Federal States, 2017) on structurally similar read across substance phosphorus (3+) trichloride (CAS no 7719-12-2), rat were treated with phosphorus (3+) trichloride in the concentration of18 mg/kg bw orally. 50 % mortality was observed in treated rats at 18 mg/kg bw. Therefore, LD50 was considered to be18 mg/kg bw when rat were treated with phosphorus (3+) trichloride orally.
Thus, based on the above study on phosphorus (3+) tribromide and its read across substances, it can be concluded that LD50 value is less than 50 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, phosphorus (3+) tribromideacetate can be classified as Category II of acute oral toxicity.
Justification for classification or non-classification
Based on the above study on phosphorus (3+) tribromide and its read across substances, it can be concluded that LD50 value is less than 50 mg/kg bw for oral and less than 1.0 mg/L Thus, comparing this value with the criteria of CLP regulation, phosphorus (3+) tribromideacetate can be classified as Category II of acute oral toxicity.
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