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Diss Factsheets
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EC number: 700-372-0 | CAS number: 1128026-41-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted at a GLP-accredited testing facility
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Details on test material:
- The test material was not 2-oxa-7-thia-3,8-disiladecane, 3,3-dimethoxy-8,8,9,9-tetramethyl- (CAS RN 1128026-41-4) but 2-oxa-7-thia-3,8-disiladecane, 3-methoxy-3,8,8,9,9-pentamethyl- (CAS RN 927395-20-8). Both substances are poorly soluble in water and are rapidly hydrolysed to give t-butyldimethylsilanol and either 3-(trimethoxymethylsilyl)-propane-1-thiol or 3-(dimethoxymethylsilyl)-propane-1-thiol respectively.
Both 3-(trimethoxymethylsilyl)-propane-1-thiol and 3-(dimethoxymethylsilyl)-propane-1-thiol volatalise from the culture medium, meaning that effectve exposure is to the same hydrolysis product in both cases, t-butyldimethylsilanol.
Analytical purity: 99.7% (gas chromatography)
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Preliminary chemical analysis showed the test material to be poorly soluble in water and to rapidly degrade in the test medium, with a half-life of approximately 24 minutes. The degradation product was also unstable in the test medium, with none detected after approximately 8 hours. Consequently, in the definitive test the analysis of the test preparations was based on total organic carbon (TOC).
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Test solutions were prepared by stirring 1000mg of test material in reconstituted water at approximately 7500rpm for approximately 40 minutes. The volume was adjusted to 2l to give a 500mg/l stock solution. Undissolved test material was removed via filtration through a 0.2µm Sartorius Sartopore filter, with the initial 500ml being discarded to precondition the filter. The solution was then left to stand for 24h to produce a saturated solution with a nominal concentration of 77mg/l (based on TOC analysis at 0h). The saturated solution was serially diluted to prepare the remainder of the test series.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- First instar animals derived from in-house laboratory cultures.
Adults were maintained in polypropylene vessels containing ca. 2l reconstituted water and a temperature-controlled room at ca. 20°C
Lighting cycle: 16h/8h light/dark with 20 minute dawn and dusk transition periods.
Each culture was fed daily with algae (Chlorella sp.)
Culture conditions ensured that reproduction was by parthogenesis
Gravid adults were isolated the day before initiation of the test, such that the young daphnids produced overnight were less than 24h old
The young were removed from the cultures and used for testing
Diet and diluent water were considered not to contain any contaminant that would affect the integrity or outcome of the study.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- None
Test conditions
- Hardness:
- 250mg/l (as CaCO3, theoretical)
- Test temperature:
- 20.3-20.9°C
- pH:
- 8.0-8.1
- Dissolved oxygen:
- 8.1-8.8mg O2/l
- Salinity:
- ot applcable
- Nominal and measured concentrations:
- nominal: 0, 0.77, 1.4, 2.5, 4.3, 7.7, 14, 25, 43, and 77mg/l
measured (0h, as TOC): <1, <1, <1, <1, 1.77, 3.27, 6.01, 10.73, 19.29, and 34.10 mg C/l
measured (0h, as parent test material): NQ, NQ, NQ, NQ, 3.62, 6.68, 12.3, 21.9, 39.4, and 69.7mg/l
measured (48h, as TOC): <1, <1, <1, <1, 1.30, 2.79, 4.32, 9.20, 17.06, 30.62 mg C/l
measured (48h, as parent test material): NQ, NQ, NQ, NQ, 2.66, 5.70, 8.83, 18.8, 34.9, 62.6mg/l
NQ: not quantifiable, below the limit of quantitation (1mg C/l) - Details on test conditions:
- 250ml glass jars containing approx. 200ml of test solution. 10 daphnids were placed in each test solution and control at random. Duplicate vessels were used for each test and control group
Vessels were covered to reduce evaporation and maintained in a temperature-controlled room. Lighting cycle: 16h/8h light/dark with 20 minute dawn and dusk transition periods
Daphnids were not fed during the treatment period and the test vessels were not aerated. Test preparations were not renewed during the exposure period.
Vessels were gently agitated at 24h and 48h. Daphnids were considered to be immobilised if they were unable to swim for approximately 15 seconds after agitation.
TEST MEDIUM
Reconstituted water was prepared from deionised water (conductivity <5 µS/cm) to which 25ml of the following stock solutions were added to each litre (final volume):
calclium dichloride dihydrate 11.76g/l
magnesium sulphate heptahydrate 4.93 g/l
sodium bicarbonate 2.59g/l
potassium chloride 0.23g/l
The reconstituted water had a pH of 7.8±0.2, adjusted with HCl or NaOH as necessary. It was aerated until the dissolved oxygen concentration approximated that or air saturation. - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 87 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL = 59-210mg/l
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 14 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL = 11-16mg/l
- Results with reference substance (positive control):
- A positive control study is conducted at the laboratory approximately every six months. The EC50 at 24h was 1.2mg/l (95% CL 1.0-1.4) and at 48h was 0.85mg/l (95% CL 0.76-0.96).
Applicant's summary and conclusion
- Conclusions:
- The test substance is poorly soluble in water and rapidly hydrolyses. As a consequence, dilutions of a saturated solution were made and nominal concentrations compared to TOC analysis. The EC50 at 48h, based on nominal concentration, was 14mg/l (95% CL 11-16mg/l).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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